Pss Phosphatidylserine synthase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pssprovided by FlyBase
Official Full Name: Phosphatidylserine synthaseprovided by FlyBase
Primary source: FLYBASE:FBgn0287585
Locus tag: Dmel_CG4825
See related: AllianceGenome:FB:FBgn0287585
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4825; Dmel\CG4825; l(3)04521; l(3)77CDf; pss; ptdss1
Summary: Enables phosphotransferase activity, for other substituted phosphate groups. Involved in phosphatidylserine biosynthetic process. Located in endomembrane system. Is expressed in adult brain cell body rind; adult fat body; adult gnathal ganglion; and adult head. Human ortholog(s) of this gene implicated in Lenz-Majewski hyperostotic dwarfism. Orthologous to human PTDSS1 (phosphatidylserine synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 77C6-77C7; 3-47 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20522440..20526174, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20515540..20519274, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrate the tissue-autonomous function of CG4825 in regulating cell growth and lipid storage.
Title: Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms.

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables L-serine-phosphatidylcholine phosphatidyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphotransferase activity, for other substituted phosphate groups	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylserine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylserine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylserine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed

General protein information

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Preferred Names: phosphatidylserine synthase

Names: CDP-diacylglycerol-serine O-phosphatidyltransferase; CG4825-PA; CG4825-PB; Pss-PA; Pss-PB; lethal (3) 77CDf

NP_001262118.1

EC 2.7.8.-

EC 2.7.8.29

NP_649242.1

EC 2.7.8.-

EC 2.7.8.29

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

20522440..20526174 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275189.1 → NP_001262118.1 phosphatidylserine synthase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262118.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PIC3

Conserved Domains (1) summary

pfam03034
Location:150 → 425

PSS; Phosphatidyl serine synthase
NM_140985.4 → NP_649242.1 phosphatidylserine synthase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649242.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9PIC3, Q9VPD3

Related

FBpp0077872

Conserved Domains (1) summary

pfam03034
Location:150 → 425

PSS; Phosphatidyl serine synthase