U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

knrl knirps-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40285, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
knrlprovided by FlyBase
Official Full Name
knirps-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0001323
Locus tag
Dmel_CG4761
See related
AllianceGenome:FB:FBgn0001323
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4761; Dmel\CG4761; knl; Knrl; NR0A2
Summary
Predicted to enable estrogen response element binding activity and nuclear receptor activity. Involved in negative regulation of DNA-templated transcription and regulation of mitotic nuclear division. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; epithelium; gut section; head epidermis primordium; and tracheal primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See knrl in Genome Data Viewer
Location:
77D4-77E1; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20597141..20620659, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20590241..20613759, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46326 Neighboring gene long noncoding RNA: testis-specific 3 Neighboring gene long non-coding RNA:CR44684 Neighboring gene long non-coding RNA:CR44683 Neighboring gene long non-coding RNA:CR44680

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Redundant functions of the genes knirps and knirps-related for the establishment of anterior Drosophila head structures. González-Gaitán M, et al. Proc Natl Acad Sci U S A, 1994 Aug 30. PMID 8078924, Free PMC Article
  2. The Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily. Oro AE, et al. Nature, 1988 Dec 1. PMID 2848202
  3. The evolution of the knirps family of transcription factors in arthropods. Naggan Perl T, et al. Mol Biol Evol, 2013 Jun. PMID 23493255
  4. Three hormone receptor-like Drosophila genes encode an identical DNA-binding finger. Rothe M, et al. EMBO J, 1989 Oct. PMID 2555153, Free PMC Article
  5. Steroid hormone receptor homologs in development. Oro AE, et al. Development, 1989. PMID 2699853

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell migration, open tracheal system TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
knirps-like
Names
CG4761-PA
CG4761-PB
Knirps-related
knirps related
knrl-PA
knrl-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20597141..20620659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176374.2 → NP_788552.1  knirps-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788552.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P13054, Q9VPC8
    UniProtKB/TrEMBL
    A0A0S0WNG8
    Related
    FBpp0077870
    Conserved Domains (1) summary
    cl02596
    Location:12 → 96
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

  2. NM_001316439.1 → NP_001303368.1  knirps-like, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P13054, Q9VPC8
    UniProtKB/TrEMBL
    A0A0S0WNG8
    Conserved Domains (1) summary
    cl02596
    Location:12 → 96
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WNG8 A0A0S0WNG8
P13054.1 P13054

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous