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Sems Seminase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40315, updated on 9-Dec-2024

Summary

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Official Symbol
Semsprovided by FlyBase
Official Full Name
Seminaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037036
Locus tag
Dmel_CG10586
See related
AllianceGenome:FB:FBgn0037036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10586; Dmel\CG10586; sems; SP168
Summary
Enables serine hydrolase activity. Involved in negative regulation of female receptivity, post-mating; sperm storage; and zymogen activation. Located in extracellular space. Is expressed in adult head and male accessory gland. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Sems in Genome Data Viewer
Location:
78A1-78A1; 3-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20955755..20956750, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20948855..20949850, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fringe Neighboring gene long non-coding RNA:CR45243 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of Drosophila-based endpoints for the assessment and understanding of xenobiotic-mediated male reproductive adversities. Misra S, et al. Toxicol Sci, 2014 Sep. PMID 24973093, Free PMC Article
  2. A Drosophila protease cascade member, seminal metalloprotease-1, is activated stepwise by male factors and requires female factors for full activity. Laflamme BA, et al. Genetics, 2014 Apr. PMID 24514904, Free PMC Article
  3. Drosophila seminal sex peptide associates with rival as well as own sperm, providing SP function in polyandrous females. Misra S, et al. Elife, 2020 Jul 16. PMID 32672537, Free PMC Article
  4. Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. Mulligan KA, et al. Proc Natl Acad Sci U S A, 2012 Jan 10. PMID 22203956, Free PMC Article
  5. Long-term interaction between Drosophila sperm and sex peptide is mediated by other seminal proteins that bind only transiently to sperm. Singh A, et al. Insect Biochem Mol Biol, 2018 Nov. PMID 30217614, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of female receptivity, post-mating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in sexual reproduction HEP PubMed 
involved_in sperm storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in zymogen activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 

General protein information

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Preferred Names
seminase
Names
CG10586-PA
Sems-PA
NP_649270.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20955755..20956750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141013.2 → NP_649270.1  seminase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649270.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C1C3F2, Q4QQ23, Q4QQ30, Q9VP95
    Related
    FBpp0077991
    Conserved Domains (2) summary
    smart00020
    Location:43 → 263
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:44 → 265
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VP95.1 Q9VP95

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