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CG10588 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40316, updated on 9-Dec-2024

Summary

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Official Symbol
CG10588provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037037
Locus tag
Dmel_CG10588
See related
AllianceGenome:FB:FBgn0037037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10588
Summary
Predicted to enable protein folding chaperone. Predicted to be involved in chaperone-mediated protein folding. Predicted to be active in mitochondrial matrix. Is expressed in spermatozoon. Orthologous to human NRDC (nardilysin convertase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG10588 in Genome Data Viewer
Location:
78A1-78A1; 3-47 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20956934..20960660)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20950034..20953760)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45243 Neighboring gene Seminase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of 11-amino acid peptides that disrupt Notch-mediated processes in Drosophila. Pi H, et al. J Biomed Sci, 2011 Jun 17. PMID 21682860, Free PMC Article
  2. Differential gene expression related to Nora virus infection of Drosophila melanogaster. Cordes EJ, et al. Virus Res, 2013 Aug. PMID 23603562, Free PMC Article
  3. Retrogene movement within- and between-chromosomes in the evolution of Drosophila genomes. Dai H, et al. Gene, 2006 Dec 30. PMID 17101240
  4. Drosophila sperm proteome evolution: Insights from comparative genomic approaches. Rettie EC, et al. Spermatogenesis, 2012 Jul 1. PMID 23087838, Free PMC Article
  5. Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. Krauchunas AR, et al. Dev Biol, 2012 Oct 1. PMID 22884528, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein folding chaperone ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10588-PA
CG10588-PB
NP_001287135.1
NP_649271.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20956934..20960660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300206.1 → NP_001287135.1  uncharacterized protein Dmel_CG10588, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287135.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6IDT7, Q9VP94
    Conserved Domains (4) summary
    COG1025
    Location:27 → 980
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:85 → 214
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:244 → 419
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam16187
    Location:436 → 720
    Peptidase_M16_M; Middle or third domain of peptidase_M16

  2. NM_141014.2 → NP_649271.1  uncharacterized protein Dmel_CG10588, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6IDT7, Q9VP94
    Related
    FBpp0077942
    Conserved Domains (4) summary
    COG1025
    Location:27 → 980
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:85 → 214
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:244 → 419
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam16187
    Location:436 → 720
    Peptidase_M16_M; Middle or third domain of peptidase_M16
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VP94 Q9VP94

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