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ko knockout [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40330, updated on 9-Dec-2024

Summary

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Official Symbol
koprovided by FlyBase
Official Full Name
knockoutprovided by FlyBase
Primary source
FLYBASE:FBgn0020294
Locus tag
Dmel_CG10573
See related
AllianceGenome:FB:FBgn0020294
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10573; Dmel\CG10573
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in motor neuron axon guidance. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including amnioproctodeal invagination; embryonic head epidermis; embryonic/larval dorsal vessel; gut section; and larval somatic muscle cell. Human ortholog(s) of this gene implicated in pre-eclampsia. Orthologous to human STOX1 (storkhead box 1) and STOX2 (storkhead box 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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Location:
78B1-78B2; 3-47 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21075581..21131159, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21068681..21124259, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit E Neighboring gene schizo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45945 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Islet cell autoantigen 69 kDa Neighboring gene Adenylyl cyclase 78C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Class of Visual Neurons with Wide-Field Properties Is Required for Local Motion Detection. Fisher YE, et al. Curr Biol, 2015 Dec 21. PMID 26670999
  2. Krüppel target gene knockout participates in the proper innervation of a specific set of Drosophila larval muscles. Hartmann C, et al. EMBO J, 1997 Sep 1. PMID 9311990, Free PMC Article
  3. Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during aging. Jauregui-Lozano J, et al. Aging Cell, 2022 Feb. PMID 35048512, Free PMC Article
  4. Wnt4 is a local repulsive cue that determines synaptic target specificity. Inaki M, et al. Curr Biol, 2007 Sep 18. PMID 17764943
  5. Fear-of-intimacy-mediated zinc transport controls the function of zinc-finger transcription factors involved in myogenesis. Carrasco-Rando M, et al. Development, 2016 Jun 1. PMID 27068109

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
knockout
Names
CG10573-PA
CG10573-PB
ko-PA
ko-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21075581..21131159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079469.3 → NP_524193.2  knockout, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524193.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWN7, Q9VP79
    Related
    FBpp0077980
    Conserved Domains (1) summary
    pfam10264
    Location:119 → 195
    Stork_head; Winged helix Storkhead-box1 domain

  2. NM_001275206.1 → NP_001262135.1  knockout, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262135.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWN7, Q9VP79
    Conserved Domains (1) summary
    pfam10264
    Location:119 → 195
    Stork_head; Winged helix Storkhead-box1 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18363 O18363
Q6AWN7 Q6AWN7
Q9VP79 Q9VP79

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