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LERFS lncRNA negative regulator of fibroblast-like synoviocyte migration, SYNCRIP interacting [ Homo sapiens (human) ]

Gene ID: 403323, updated on 22-Oct-2024

Summary

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Official Symbol
LERFSprovided by HGNC
Official Full Name
lncRNA negative regulator of fibroblast-like synoviocyte migration, SYNCRIP interactingprovided by HGNC
Primary source
HGNC:HGNC:51182
See related
Ensembl:ENSG00000234665 AllianceGenome:HGNC:51182
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 2.4), thyroid (RPKM 2.1) and 25 other tissues See more
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Genomic context

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See LERFS in Genome Data Viewer
Location:
9q13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (62857856..62898087, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (80284687..80324093)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (66513680..66553911, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene PTGER4P2-CDK2AP2P2 readthrough, transcribed pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66500322-66500855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:66508451-66508950 Neighboring gene cyclin dependent kinase 2 associated protein 2 pseudogene 2 Neighboring gene prostaglandin E receptor 4 pseudogene 2 Neighboring gene myosin VB pseudogene 2 Neighboring gene adhesion G protein-coupled receptor F5 pseudogene 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:66530343-66531053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28435 Neighboring gene fibroblast growth factor 7 pseudogene 8 Neighboring gene family with sequence similarity 88 member B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:66570705-66571492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:66571493-66572278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:66581406-66581906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:66581907-66582407 Neighboring gene CNTNAP3 pseudogene 1 Neighboring gene coiled-coil domain-containing protein 86-like Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr9:66950247-66950746

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation. Zou Y, et al. J Clin Invest, 2018 Oct 1. PMID 30198906, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Other Names

  • lowly expressed in rheumatoid fibroblast-like synoviocytes

Clone Names

  • FLJ97721, FLJ99937

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_122076.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL512625

  2. NR_122077.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate splice site in the 5' terminal exon, lacks multiple 3' exons, and contains an alternate 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AK000451
    Related
    ENST00000849149.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    62857856..62898087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    80284687..80324093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_203449.1: Suppressed sequence

    Description
    NM_203449.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version

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