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Ac78C Adenylyl cyclase 78C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40333, updated on 4-Jan-2025

Summary

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Official Symbol
Ac78Cprovided by FlyBase
Official Full Name
Adenylyl cyclase 78Cprovided by FlyBase
Primary source
FLYBASE:FBgn0024150
Locus tag
Dmel_CG10564
See related
AllianceGenome:FB:FBgn0024150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AC 78C; AC78C; CG10554; CG10564; DAC78C; DAC78C-s; dADCY8; Dmel\CG10564
Summary
Enables adenylate cyclase activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of sweet taste; response to caffeine; and response to disaccharide. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; antennal anlage; central brain anlage; dorsal ectoderm; and epithelial furrow. Orthologous to human ADCY8 (adenylate cyclase 8). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ac78C in Genome Data Viewer
Location:
78B3-78C1; 3-47 cM
Exon count:
25
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21136447..21171930, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21129547..21165030, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene knockout Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Islet cell autoantigen 69 kDa Neighboring gene Asparagine synthetase Neighboring gene chromosome bows Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses. Yoon W, et al. Commun Biol, 2022 Aug 25. PMID 36008531, Free PMC Article
  2. Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Jan. PMID 10603085
  3. Pigment-Dispersing Factor Signaling and Circadian Rhythms in Insect Locomotor Activity. Shafer OT, et al. Curr Opin Insect Sci, 2014 Jul 1. PMID 25386391, Free PMC Article
  4. Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration. Hertzler JI, et al. PLoS Genet, 2024 Aug. PMID 39186815, Free PMC Article
  5. Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Ueno K, et al. Eur J Neurosci, 2008 Nov. PMID 19046378

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration.
    Title: Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration.
  2. We conclude that AC78C, via cAMP, participates in the sugar-taste signaling pathway at the low concentration range.
    Title: Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster.
Submit: New GeneRIF Correction

General gene information

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Homology

mobile_element

  • Loc: c21143429-21143362 mobile_element_type = transposon:INE-1{}5891

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of sweet taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in response to caffeine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to sucrose IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to trehalose IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adenylyl cyclase 78C
Names
Ac78C-PB
Ac78C-PC
Ac78C-PD
Ac78C-PE
Ac78C-PF
CG10564-PB
CG10564-PC
CG10564-PD
CG10564-PE
CG10564-PF
adenylyl cyclase
NP_001246857.1
NP_001262137.1
NP_001262138.1
NP_001262139.1
NP_524194.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21136447..21171930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275210.1 → NP_001262139.1  adenylyl cyclase 78C, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262139.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PD54, Q9U9I8, Q9Y1V0
    Conserved Domains (4) summary
    smart00044
    Location:525 → 728
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:1380 → 1575
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:928 → 1019
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:287 → 550
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  2. NM_001275209.1 → NP_001262138.1  adenylyl cyclase 78C, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262138.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PID8, Q9U9I8, Q9Y1V0
    Conserved Domains (4) summary
    smart00044
    Location:526 → 729
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:1381 → 1576
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:929 → 1020
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:288 → 551
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  3. NM_079470.5 → NP_524194.3  adenylyl cyclase 78C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524194.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NG95, Q9VP75, Q9VP76
    UniProtKB/TrEMBL
    Q9U9I8, Q9Y1V0
    Conserved Domains (4) summary
    smart00044
    Location:526 → 729
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:1381 → 1576
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:929 → 1020
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:288 → 551
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  4. NM_001275208.1 → NP_001262137.1  adenylyl cyclase 78C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262137.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG27, Q9U9I8, Q9Y1V0
    Conserved Domains (4) summary
    smart00044
    Location:502 → 705
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:1357 → 1552
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:905 → 996
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:264 → 527
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  5. NM_001259928.2 → NP_001246857.1  adenylyl cyclase 78C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246857.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KLG6
    Conserved Domains (3) summary
    smart00044
    Location:30 → 233
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:885 → 1080
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:433 → 524
    DUF1053; Domain of Unknown Function (DUF1053)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PD54 M9PD54
M9PG27 M9PG27
M9PID8 M9PID8
Q7KLG6 Q7KLG6
Q9VP76.3 Q9VP76
Q9Y1V0 Q9Y1V0

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