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Trmt112 tRNA methyltransferase subunit 11-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40343, updated on 4-Jan-2025

Summary

Official Symbol
Trmt112provided by FlyBase
Official Full Name
tRNA methyltransferase subunit 11-2provided by FlyBase
Primary source
FLYBASE:FBgn0037061
Locus tag
Dmel_CG12975
See related
AllianceGenome:FB:FBgn0037061
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE57810; CG12975; Dmel\CG12975
Summary
Predicted to enable tRNA methyltransferase activator activity. Involved in rRNA methylation. Predicted to be part of tRNA (m2G10) methyltransferase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Trmt112 in Genome Data Viewer
Location:
78C2-78C2; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21215995..21216839, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21209095..21209939, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Terminal ADP-ribose protein glycohydrolase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Integrin linked kinase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA methyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in rRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of tRNA (m2G10) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of tRNA (m2G10) methyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tRNA methyltransferase subunit 11-2
Names
CG12975-PA
Trmt112-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21215995..21216839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141036.4NP_649293.1  tRNA methyltransferase subunit 11-2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649293.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1B2AL65, Q9VP65
    Related
    FBpp0077965
    Conserved Domains (1) summary
    pfam03966
    Location:90113
    Trm112p; Trm112p-like protein