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BRCA1 BRCA1 DNA repair associated [ Canis lupus familiaris (dog) ]

Gene ID: 403437, updated on 17-Aug-2024

Summary

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Official Symbol
BRCA1provided by VGNC
Official Full Name
BRCA1 DNA repair associatedprovided by VGNC
Primary source
VGNC:VGNC:38516
See related
Ensembl:ENSCAFG00845006070
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
27
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (20677057..20743989)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (19422566..19486083)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (19833116..19896786)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (19464421..19527988)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (19730981..19794752)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene coiled-coil domain containing 200 Neighboring gene transmembrane protein 106A Neighboring gene NBR1 autophagy cargo receptor Neighboring gene Rho family GTPase 2 Neighboring gene vesicle amine transport 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Promoter mutation and reduced expression of BRCA1 in canine mammary tumors. Qiu HB, et al. Res Vet Sci, 2015 Dec. PMID 26679809
  2. Relationship between three novel SNPs of BRCA1 and canine mammary tumors. Sun W, et al. J Vet Med Sci, 2015 Nov. PMID 26156012, Free PMC Article
  3. Expression patterns of the BRCA1 splicing variants in canine normal tissues and mammary gland tumors. Sugiura T, et al. J Vet Med Sci, 2007 Jun. PMID 17611353
  4. A single nucleotide (T-->G) polymorphism within intron 23 of the canine BRCA1 gene. Gray IS, et al. Anim Genet, 2000 Feb. PMID 10690375
  5. Genetic variations of BRCA1 and BRCA2 genes in dogs with mammary tumours. Enginler SO, et al. Vet Res Commun, 2014 Mar. PMID 24122022

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Three previously unreported single-nucleotide polymorphisms in BRCA1 in canine mammary tumors are reported.
    Title: Relationship between three novel SNPs of BRCA1 and canine mammary tumors.
  2. 46.7% of the malignant mammary tumors were found with a deletion of one cytosine in the promoter region. mRNA expression of BRCA1 was significantly reduced in benign and malignant mammary tumors.
    Title: Promoter mutation and reduced expression of BRCA1 in canine mammary tumors.
  3. one SNP in exon 9 of BRCA1 and one SNP in exon 24 of BRCA2 were found to be significantly associated with canine mammary tumours
    Title: Genetic variations of BRCA1 and BRCA2 genes in dogs with mammary tumours.
  4. this study indicates that BRCA1 and BRCA2 contribute to the risk of canine mammary tumors in English springer spaniels
    Title: Mammary tumor development in dogs is associated with BRCA1 and BRCA2.
  5. The expression of multiple splice variants of BRCA1 in mammary gland tumors of dogs is reported.
    Title: Expression patterns of the BRCA1 splicing variants in canine normal tissues and mammary gland tumors.
  6. The amino terminal RING finger motif and the granin consensus sequence are conserved between human, canine, and murine BRCA1 genes.
    Title: Human, canine and murine BRCA1 genes: sequence comparison among species.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein homolog
Names
BRCA1 homolog
RING-type E3 ubiquitin transferase BRCA1
breast and ovarian cancer susceptibility protein 1
NP_001013434.1
XP_038530837.1
XP_038530838.1
XP_038530840.1
XP_038530841.1
XP_038530842.1
XP_038530843.1
XP_038530844.1
XP_038530845.1
XP_038530846.1
XP_038530847.1
XP_038530848.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013416.1 → NP_001013434.1  breast cancer type 1 susceptibility protein homolog

    See identical proteins and their annotated locations for NP_001013434.1

    Status: PROVISIONAL

    Source sequence(s)
    U50709
    UniProtKB/Swiss-Prot
    Q95153
    UniProtKB/TrEMBL
    A0A8C0T715
    Conserved Domains (4) summary
    smart00292
    Location:1766 → 1850
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1653 → 1727
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:342 → 505
    BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    20677057..20743989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038674913.1 → XP_038530841.1  breast cancer type 1 susceptibility protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A8C0RAM3, A0A8C0T715
    Conserved Domains (4) summary
    cd16498
    Location:18 → 78
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1779 → 1876
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1666 → 1762
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:355 → 518
    BRCT_assoc; Serine-rich domain associated with BRCT

  2. XM_038674915.1 → XP_038530843.1  breast cancer type 1 susceptibility protein homolog isoform X4

    UniProtKB/TrEMBL
    A0A8C0RAP1, A0A8C0T715, A0A8I3N406
    Related
    ENSCAFP00845008432.1, ENSCAFT00845010804.1
    Conserved Domains (5) summary
    TIGR00599
    Location:15 → 121
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1766 → 1863
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:342 → 505
    BRCT_assoc; Serine-rich domain associated with BRCT

  3. XM_038674918.1 → XP_038530846.1  breast cancer type 1 susceptibility protein homolog isoform X5

    UniProtKB/TrEMBL
    A0A8C0T715
    Conserved Domains (5) summary
    TIGR00599
    Location:58 → 164
    rad18; DNA repair protein rad18
    cd16498
    Location:61 → 108
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1696 → 1792
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:385 → 548
    BRCT_assoc; Serine-rich domain associated with BRCT
    cl00038
    Location:1809 → 1829
    BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains

  4. XM_038674909.1 → XP_038530837.1  breast cancer type 1 susceptibility protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A8C0T715
    Conserved Domains (4) summary
    cd16498
    Location:61 → 121
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1822 → 1919
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1709 → 1805
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:398 → 561
    BRCT_assoc; Serine-rich domain associated with BRCT

  5. XM_038674910.1 → XP_038530838.1  breast cancer type 1 susceptibility protein homolog isoform X2

    UniProtKB/TrEMBL
    A0A8C0T715
    Conserved Domains (5) summary
    TIGR00599
    Location:58 → 164
    rad18; DNA repair protein rad18
    cd16498
    Location:61 → 108
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1809 → 1906
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1696 → 1792
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:385 → 548
    BRCT_assoc; Serine-rich domain associated with BRCT

  6. XM_038674919.1 → XP_038530847.1  breast cancer type 1 susceptibility protein homolog isoform X6

    UniProtKB/TrEMBL
    A0A8C0T776, A0A8I3MXX4
    Conserved Domains (3) summary
    cd16498
    Location:61 → 121
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:712 → 809
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:599 → 695
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  7. XM_038674920.1 → XP_038530848.1  breast cancer type 1 susceptibility protein homolog isoform X7

    UniProtKB/TrEMBL
    A0A8C0T776, A0A8I3MXX4
    Related
    ENSCAFP00845008453.1, ENSCAFT00845010832.1
    Conserved Domains (4) summary
    TIGR00599
    Location:58 → 164
    rad18; DNA repair protein rad18
    cd16498
    Location:61 → 108
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:699 → 796
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:586 → 682
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  8. XM_038674914.1 → XP_038530842.1  breast cancer type 1 susceptibility protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A8C0RAM3, A0A8C0T715
    Conserved Domains (4) summary
    cd16498
    Location:18 → 78
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1779 → 1876
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1666 → 1762
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:355 → 518
    BRCT_assoc; Serine-rich domain associated with BRCT

  9. XM_038674912.1 → XP_038530840.1  breast cancer type 1 susceptibility protein homolog isoform X3

    UniProtKB/TrEMBL
    A0A8C0RAM3, A0A8C0T715
    Conserved Domains (4) summary
    cd16498
    Location:18 → 78
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1779 → 1876
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1666 → 1762
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:355 → 518
    BRCT_assoc; Serine-rich domain associated with BRCT

  10. XM_038674917.1 → XP_038530845.1  breast cancer type 1 susceptibility protein homolog isoform X4

    UniProtKB/TrEMBL
    A0A8C0RAP1, A0A8C0T715, A0A8I3N406
    Conserved Domains (5) summary
    TIGR00599
    Location:15 → 121
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1766 → 1863
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:342 → 505
    BRCT_assoc; Serine-rich domain associated with BRCT

  11. XM_038674916.1 → XP_038530844.1  breast cancer type 1 susceptibility protein homolog isoform X4

    UniProtKB/TrEMBL
    A0A8C0RAP1, A0A8C0T715, A0A8I3N406
    Conserved Domains (5) summary
    TIGR00599
    Location:15 → 121
    rad18; DNA repair protein rad18
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:1766 → 1863
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1653 → 1749
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:342 → 505
    BRCT_assoc; Serine-rich domain associated with BRCT

RNA

  1. XR_005431678.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    19464421..19527988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    19730981..19794752
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    19833116..19896786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    19422566..19486083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95153.1 GenPept UniProtKB/Swiss-Prot:Q95153

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