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Eip78C Ecdysone-induced protein 78C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40345, updated on 4-Jan-2025

Summary

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Official Symbol
Eip78Cprovided by FlyBase
Official Full Name
Ecdysone-induced protein 78Cprovided by FlyBase
Primary source
FLYBASE:FBgn0004865
Locus tag
Dmel_CG18023
See related
AllianceGenome:FB:FBgn0004865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0172774.42; anon-WO0172774.44; CG18023; dE78; Dmel\CG18023; DR-78; E78; E78A; E78B; E78D; Eip 78C; Eip78; eip78c; Eip78c; EIP78C; Eip78D; NR1E1
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Is expressed in border follicle cell; main body follicle cell; nurse cell; and organism. Human ortholog(s) of this gene implicated in brain small vessel disease. Orthologous to several human genes including NR1D2 (nuclear receptor subfamily 1 group D member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Eip78C in Genome Data Viewer
Location:
78C2-78C3; 3-47 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21226609..21266503)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21219709..21259603)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Integrin linked kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45162 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila 78C early late puff contains E78, an ecdysone-inducible gene that encodes a novel member of the nuclear hormone receptor superfamily. Stone BL, et al. Cell, 1993 Oct 22. PMID 8402914
  2. DR-78, a novel Drosophila melanogaster genomic DNA fragment highly homologous to the DNA-binding domain of thyroid hormone-retinoic acid-vitamin D receptor subfamily. Martín-Blanco E, et al. Biochim Biophys Acta, 1993 Nov 16. PMID 8241283
  3. PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43. Joardar A, et al. Hum Mol Genet, 2015 Mar 15. PMID 25432537, Free PMC Article
  4. The Drosophila E78 nuclear receptor regulates dietary triglyceride uptake and systemic lipid levels. Praggastis SA, et al. Dev Dyn, 2021 May. PMID 33368768, Free PMC Article
  5. The induction of DNA puff BhC4-1 gene is a late response to the increase in 20-hydroxyecdysone titers in last instar dipteran larvae. Basso LR Jr, et al. Mech Dev, 2002 Jan. PMID 11744365

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Drosophila E78 nuclear receptor regulates dietary triglyceride uptake and systemic lipid levels.
    Title: The Drosophila E78 nuclear receptor regulates dietary triglyceride uptake and systemic lipid levels.
  2. Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila.
    Title: Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 21243800-21251305 mobile_element_type = transposon:412{}1075
  • Loc: 21243865-21251304 mobile_element_type = transposon:412{}922

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ecdysone-induced protein 78C
Names
CG18023-PA
CG18023-PB
CG18023-PD
CG18023-PE
Eip78C-PA
Eip78C-PB
Eip78C-PD
Eip78C-PE
ecdysone induced protein 78C
nuclear hormone receptor
NP_730609.3
  • non-AUG (CUG) translation initiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21226609..21266503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259933.1 → NP_001246862.1  Ecdysone-induced protein 78C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246862.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18395, O18396, P45447, Q7KTW8, Q8IPT7, Q9NBW8, Q9NBW9, Q9VP64
    UniProtKB/TrEMBL
    M9NDE9
    Conserved Domains (2) summary
    cd06941
    Location:659 → 854
    NR_LBD_DmE78_like; The ligand binding domain of Drosophila ecdysone-induced protein 78, a member of the nuclear receptor superfamily
    cd07165
    Location:363 → 443
    NR_DBD_DmE78_like; DNA-binding domain of Drosophila ecdysone-induced protein 78 (E78) like is composed of two C4-type zinc fingers

  2. NM_001259934.1 → NP_001246863.1  Ecdysone-induced protein 78C, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246863.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18395, O18396, P45447, Q7KTW8, Q8IPT7, Q9NBW8, Q9NBW9, Q9VP64
    UniProtKB/TrEMBL
    M9NDE9
    Conserved Domains (2) summary
    cd06941
    Location:659 → 854
    NR_LBD_DmE78_like; The ligand binding domain of Drosophila ecdysone-induced protein 78, a member of the nuclear receptor superfamily
    cd07165
    Location:363 → 443
    NR_DBD_DmE78_like; DNA-binding domain of Drosophila ecdysone-induced protein 78 (E78) like is composed of two C4-type zinc fingers

  3. NM_079471.3 → NP_524195.2  Ecdysone-induced protein 78C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524195.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18395, O18396, P45447, Q7KTW8, Q8IPT7, Q9NBW8, Q9NBW9, Q9VP64
    UniProtKB/TrEMBL
    M9NDE9
    Related
    FBpp0077963
    Conserved Domains (2) summary
    cd06941
    Location:659 → 854
    NR_LBD_DmE78_like; The ligand binding domain of Drosophila ecdysone-induced protein 78, a member of the nuclear receptor superfamily
    cd07165
    Location:363 → 443
    NR_DBD_DmE78_like; DNA-binding domain of Drosophila ecdysone-induced protein 78 (E78) like is composed of two C4-type zinc fingers

  4. NM_168892.3 → NP_730609.3  Ecdysone-induced protein 78C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730609.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P45447
    Related
    FBpp0077964
    Conserved Domains (1) summary
    cd06941
    Location:189 → 384
    NR_LBD_DmE78_like; The ligand binding domain of Drosophila ecdysone-induced protein 78, a member of the nuclear receptor superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDE9 M9NDE9
P45447.4 P45447

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