U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ebd2 earthbound 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40363, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
ebd2provided by FlyBase
Official Full Name
earthbound 2provided by FlyBase
Primary source
FLYBASE:FBgn0037076
Locus tag
Dmel_CG12972
See related
AllianceGenome:FB:FBgn0037076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12972; Dmel\CG12972
Summary
Predicted to enable DNA binding activity. Involved in adult somatic muscle development. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ebd2 in Genome Data Viewer
Location:
78C8-78C8; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21344768..21349288, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21337868..21342388, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Rab26 Neighboring gene antisense RNA:CR46068 Neighboring gene Tsr1 ribosome assembly factor Neighboring gene TBC1 domain family member 8/9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. Benchabane H, et al. EMBO J, 2011 Apr 20. PMID 21399610, Free PMC Article
  2. Reduced histone gene copy number disrupts Drosophila Polycomb function. McPherson JE, et al. Genetics, 2023 Aug 9. PMID 37279945, Free PMC Article
  3. Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. Tian A, et al. PLoS Genet, 2017 Jul. PMID 28708826, Free PMC Article
  4. Inter-Species Rescue of Mutant Phenotype-The Standard for Genetic Analysis of Human Genetic Disorders in Drosophila melanogaster Model. Ecovoiu AA, et al. Int J Mol Sci, 2022 Feb 27. PMID 35269756, Free PMC Article
  5. The Landscape of the DNA Transposons in the Genome of the Horezu_LaPeri Strain of Drosophila melanogaster. Bologa AM, et al. Insects, 2023 May 25. PMID 37367310, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adult somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
earthbound 2
Names
CG12972-PA
CG12972-PB
ebd2-PA
ebd2-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21344768..21349288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259936.1 → NP_001246865.1  earthbound 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246865.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VP44
    Conserved Domains (2) summary
    smart00674
    Location:101 → 166
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam04218
    Location:27 → 80
    CENP-B_N; CENP-B N-terminal DNA-binding domain

  2. NM_141050.3 → NP_649307.1  earthbound 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649307.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VP44
    Related
    FBpp0078057
    Conserved Domains (2) summary
    smart00674
    Location:101 → 166
    CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
    pfam04218
    Location:27 → 80
    CENP-B_N; CENP-B N-terminal DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VP44 Q9VP44

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools