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M6 M6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40383, updated on 9-Dec-2024

Summary

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Official Symbol
M6provided by FlyBase
Official Full Name
M6provided by FlyBase
Primary source
FLYBASE:FBgn0037092
Locus tag
Dmel_CG7540
See related
AllianceGenome:FB:FBgn0037092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7540; dM6a; Dmel\CG7540; m6
Summary
Involved in several processes, including maintenance of epithelial integrity, open tracheal system; positive phototaxis; and tricellular tight junction assembly. Located in lateral plasma membrane and tricellular tight junction. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and ovary. Used to study intellectual disability. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to several human genes including GPM6A (glycoprotein M6A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
78D4-78D4; 3-47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21507852..21512749)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21500952..21505849)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43933 Neighboring gene Hormone-receptor-like in 78 Neighboring gene Golgi complex-localized glycoprotein 1 Neighboring gene Esterase Q Neighboring gene Sak kinase Neighboring gene Cyclin-dependent kinase 12 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Altered GPM6A/M6 dosage impairs cognition and causes phenotypes responsive to cholesterol in human and Drosophila. Gregor A, et al. Hum Mutat, 2014 Dec. PMID 25224183
  2. A role for the membrane protein M6 in the Drosophila visual system. Zappia MP, et al. BMC Neurosci, 2012 Jul 4. PMID 22762289, Free PMC Article
  3. The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin. Stecca B, et al. J Neurosci, 2000 Jun 1. PMID 10818135, Free PMC Article
  4. Palmitoylation of proteolipid protein M6 promotes tricellular junction assembly in epithelia of Drosophila. Schleutker R, et al. J Cell Sci, 2024 Mar 15. PMID 38345097
  5. The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila. Wittek A, et al. Curr Biol, 2020 Nov 2. PMID 32857972

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila.
    Title: The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila.
  2. Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
    Title: Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
  3. This study demonistrated that M6 is key in cell remodeling processes underlying visual system function.
    Title: A role for the membrane protein M6 in the Drosophila visual system.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of epithelial integrity, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive phototaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in tricellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
M6
Names
CG7540-PB
CG7540-PC
CG7540-PD
CG7540-PE
CG7540-PF
CG7540-PG
M6-PB
M6-PC
M6-PD
M6-PE
M6-PF
M6-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21507852..21512749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275237.1 → NP_001262166.1  M6, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262166.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGC0
    Conserved Domains (1) summary
    pfam01275
    Location:123 → 345
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  2. NM_001275236.1 → NP_001262165.1  M6, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262165.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFW7
    Conserved Domains (1) summary
    pfam01275
    Location:52 → 274
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  3. NM_141066.3 → NP_649323.2  M6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649323.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9A9K0, Q9VP23
    Conserved Domains (1) summary
    pfam01275
    Location:73 → 296
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  4. NM_001300214.1 → NP_001287143.1  M6, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287143.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9A9K2
    Conserved Domains (1) summary
    pfam01275
    Location:3 → 156
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  5. NM_001275235.1 → NP_001262164.1  M6, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262164.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NGC6
    Conserved Domains (1) summary
    pfam01275
    Location:1 → 225
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

  6. NM_168911.2 → NP_730642.1  M6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730642.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KI49
    Related
    FBpp0078012
    Conserved Domains (1) summary
    pfam01275
    Location:69 → 291
    Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H9A9K2 H9A9K2
M9PFW7 M9PFW7
M9PGC0 M9PGC0
Q7KI49 Q7KI49
Q9NGC6 Q9NGC6
Q9VP23 Q9VP23

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