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AGO2 argonaute RISC catalytic component 2 [ Bos taurus (domestic cattle) ]

Gene ID: 404130, updated on 1-Jan-2025

Summary

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Official Symbol
AGO2provided by VGNC
Official Full Name
argonaute RISC catalytic component 2provided by VGNC
Primary source
VGNC:VGNC:50167
See related
BGD:BT14102; Ensembl:ENSBTAG00000001579
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
EIF2C2
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See AGO2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 14 NC_037341.1 (3100810..3138228)

Chromosome 14 - NC_037341.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine kinase 2 Neighboring gene uncharacterized LOC112449596 Neighboring gene uncharacterized LOC132342171 Neighboring gene uncharacterized LOC132342172 Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene trafficking protein particle complex subunit 9 Neighboring gene microRNA mir-12027

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables endoribonuclease activity, cleaving siRNA-paired mRNA IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables miRNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein argonaute-2
Names
argonaute 2, RISC catalytic component
eukaryotic translation initiation factor 2C, 2
NP_991363.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205794.1 → NP_991363.1  protein argonaute-2

    Status: PROVISIONAL

    Source sequence(s)
    AY533678
    UniProtKB/Swiss-Prot
    Q6QME8
    UniProtKB/TrEMBL
    A0A3Q1MM22
    Related
    ENSBTAP00000072138.2, ENSBTAT00000078414.2
    Conserved Domains (5) summary
    PLN03202
    Location:26 → 859
    PLN03202; protein argonaute; Provisional
    cd02846
    Location:228 → 348
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    cd04657
    Location:393 → 818
    Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
    pfam08699
    Location:178 → 227
    ArgoL1; Argonaute linker 1 domain
    pfam16486
    Location:29 → 167
    ArgoN; N-terminal domain of argonaute

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037341.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    3100810..3138228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6QME8.1 GenPept UniProtKB/Swiss-Prot:Q6QME8

Gene LinkOut

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