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FGFR2 fibroblast growth factor receptor 2 [ Bos taurus (domestic cattle) ]

Gene ID: 404193, updated on 29-Jan-2025

Summary

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Official Symbol
FGFR2provided by VGNC
Official Full Name
fibroblast growth factor receptor 2provided by VGNC
Primary source
VGNC:VGNC:28987
See related
BGD:BT11084; Ensembl:ENSBTAG00000014064
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
FGFR
Orthologs
human mouse all
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Genomic context

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See FGFR2 in Genome Data Viewer
Location:
chromosome: 26
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (41450677..41557736, complement)

Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 11 Neighboring gene uncharacterized LOC132343967 Neighboring gene uncharacterized LOC132343968 Neighboring gene arginyltransferase 1 Neighboring gene uncharacterized LOC132343969 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene ATE1 opposite strand

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. A de novo missense mutation of FGFR2 causes facial dysplasia syndrome in Holstein cattle. Agerholm JS, et al. BMC Genet, 2017 Aug 2. PMID 28768473, Free PMC Article
  2. Conserved roles of fibroblast growth factor receptor 2 signaling in the regulation of inner cell mass development in bovine blastocysts. Akizawa H, et al. Mol Reprod Dev, 2016 Jun. PMID 27060901
  3. Fibroblast growth factor (FGF)-1, FGF2, FGF7 and FGF receptors are uniformly expressed in trophoblast giant cells during restricted trophoblast invasion in cows. Pfarrer C, et al. Placenta, 2006 Jun-Jul. PMID 16129484
  4. Detection of mRNA and immunoreactive proteins for acidic and basic fibroblast growth factor and expression of the fibroblast growth factor receptors in the bovine oviduct. Gabler C, et al. J Reprod Fertil, 1997 Mar. PMID 9155730
  5. FGF10 inhibits dominant follicle growth and estradiol secretion in vivo in cattle. Gasperin BG, et al. Reproduction, 2012 Jun. PMID 22457435

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGFR2 signaling appears to be associated with the regulation of inner cell mass development and proliferation during blastocyst formation in cattle.
    Title: Conserved roles of fibroblast growth factor receptor 2 signaling in the regulation of inner cell mass development in bovine blastocysts.
  2. activation of FGFR1 and FGFR2 by uterine- and endometrial-derived FGF2 stimulates PI3K/AKT and mitogen-activated protein kinase pathways for development of the porcine uterus and improvement of litter size
    Title: Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy.
  3. it is highly likely that the missense mutation in the FGFR2 gene caused the bovine facial dysplasia syndrome phenotype in a dominant mode of inheritance.
    Title: A de novo missense mutation of FGFR2 causes facial dysplasia syndrome in Holstein cattle.
  4. FGF10 and its receptor FGFR2b are more expressed in subordinate follicles; FGF10 acts as an important regulator of follicular growth in cattle.
    Title: FGF10 inhibits dominant follicle growth and estradiol secretion in vivo in cattle.
  5. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
    Title: Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term.
  6. These data support a role for FGF10 and fibroblast growth factor receptor 2B in signaling to granulosa cells from theca cells and/or the oocyte.(fibroblast growth factor receptor 2B)
    Title: Expression and function of fibroblast growth factor 10 and its receptor, fibroblast growth factor receptor 2B, in bovine follicles.
  7. FGF10 mRNA expression did not change during functional luteolysis, whereas FGFR2B mRNA abundance decreased significantly at 2, 4, and 12 hr after PGF2alpha, and returned to pretreatment levels for the period 24-64 hr post-PGF2alpha
    Title: Expression of fibroblast growth factor 10 and its receptor, fibroblast growth factor receptor 2B, in the bovine corpus luteum.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor 2
Names
fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
NP_001192239.1
XP_010818391.1
XP_010818393.1
XP_010818400.1
XP_024841253.1
XP_059737723.1
XP_059737724.1
XP_059737725.1
XP_059737726.1
XP_059737727.1
XP_059737728.1
XP_059737729.1
XP_059737730.1
XP_059737731.1
XP_059737732.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205310.2 → NP_001192239.1  fibroblast growth factor receptor 2 precursor

    See identical proteins and their annotated locations for NP_001192239.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000026
    UniProtKB/TrEMBL
    A7E310
    Related
    ENSBTAP00070032913.1, ENSBTAT00070054930.1
    Conserved Domains (5) summary
    cd05101
    Location:474 → 786
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:391 → 421
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275 → 278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275 → 377
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    41450677..41557736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010820098.4 → XP_010818400.1  fibroblast growth factor receptor 2 isoform X13

    See identical proteins and their annotated locations for XP_010818400.1

    UniProtKB/TrEMBL
    J9QCT8
    Related
    ENSBTAP00070032872.1, ENSBTAT00070054876.1
    Conserved Domains (4) summary
    cd05101
    Location:358 → 670
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:275 → 305
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd05857
    Location:58 → 152
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cd05858
    Location:160 → 264
    IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains

  2. XM_059881748.1 → XP_059737731.1  fibroblast growth factor receptor 2 isoform X12

    UniProtKB/TrEMBL
    J9QCT8

  3. XM_059881747.1 → XP_059737730.1  fibroblast growth factor receptor 2 isoform X11

    UniProtKB/TrEMBL
    J9QD94

  4. XM_059881745.1 → XP_059737728.1  fibroblast growth factor receptor 2 isoform X9

    UniProtKB/TrEMBL
    J9QDG0

  5. XM_059881749.1 → XP_059737732.1  fibroblast growth factor receptor 2 isoform X14

    UniProtKB/TrEMBL
    J9QDU0

  6. XM_059881746.1 → XP_059737729.1  fibroblast growth factor receptor 2 isoform X10

    UniProtKB/TrEMBL
    A0A9E8ABF4, J9QD94

  7. XM_059881744.1 → XP_059737727.1  fibroblast growth factor receptor 2 isoform X8

    UniProtKB/TrEMBL
    J9QD94

  8. XM_010820089.4 → XP_010818391.1  fibroblast growth factor receptor 2 isoform X3

    See identical proteins and their annotated locations for XP_010818391.1

    UniProtKB/TrEMBL
    A7E310, F1MNW2
    Related
    ENSBTAP00070032882.1, ENSBTAT00070054888.1
    Conserved Domains (6) summary
    cd05101
    Location:473 → 785
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:390 → 420
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:50 → 53
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cd05858
    Location:275 → 379
    IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:50 → 143
    Ig; Immunoglobulin domain

  9. XM_010820091.4 → XP_010818393.1  fibroblast growth factor receptor 2 isoform X7

    See identical proteins and their annotated locations for XP_010818393.1

    UniProtKB/TrEMBL
    J9QDM6
    Conserved Domains (6) summary
    cd05101
    Location:473 → 785
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:390 → 420
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:50 → 53
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cd05858
    Location:275 → 379
    IgI_3_FGFR2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:50 → 143
    Ig; Immunoglobulin domain

  10. XM_059881741.1 → XP_059737724.1  fibroblast growth factor receptor 2 isoform X2

    UniProtKB/TrEMBL
    A7E310

  11. XM_024985485.2 → XP_024841253.1  fibroblast growth factor receptor 2 isoform X6

    UniProtKB/TrEMBL
    J9QDM6
    Conserved Domains (5) summary
    cd05101
    Location:474 → 786
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:391 → 421
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:275 → 278
    Ig; Ig strand A [structural motif]
    cd05857
    Location:173 → 267
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:275 → 377
    Ig; Immunoglobulin domain

  12. XM_059881740.1 → XP_059737723.1  fibroblast growth factor receptor 2 isoform X1

    UniProtKB/TrEMBL
    A7E310

  13. XM_059881742.1 → XP_059737725.1  fibroblast growth factor receptor 2 isoform X4

    UniProtKB/TrEMBL
    J9QDM6

  14. XM_059881743.1 → XP_059737726.1  fibroblast growth factor receptor 2 isoform X5

    UniProtKB/TrEMBL
    A0A3Q1LRU7
Nucleotide Protein Strain
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