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Chs2 Chitin synthase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40442, updated on 9-Dec-2024

Summary

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Official Symbol
Chs2provided by FlyBase
Official Full Name
Chitin synthase 2provided by FlyBase
Primary source
FLYBASE:FBgn0029091
Locus tag
Dmel_CG7464
See related
AllianceGenome:FB:FBgn0029091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7464; chitin synthase; ChSA; CS-2; DmCS-2; DmeCHS2; DmeChSA; Dmel\CG7464
Summary
Predicted to enable chitin synthase activity. Predicted to be involved in chitin biosynthetic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Chs2 in Genome Data Viewer
Location:
79A5-79A5; 3-47 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21962401..21969964)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21955501..21963064)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45757 Neighboring gene pseudo Neighboring gene Delta[1]-pyrroline-5-carboxylate synthase Neighboring gene Actin 79B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stage-specific expression of the chitin synthase DmeChSA and DmeChSB genes during the onset of Drosophila metamorphosis. Gagou ME, et al. Insect Biochem Mol Biol, 2002 Feb. PMID 11755055
  2. Insect chitin synthase cDNA sequence, gene organization and expression. Tellam RL, et al. Eur J Biochem, 2000 Oct. PMID 10998064
  3. Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae. Chen LP, et al. Open Biol, 2016 Apr. PMID 27249340, Free PMC Article
  4. Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. Ostrowski S, et al. Genetics, 2002 May. PMID 12019232, Free PMC Article
  5. Phenotype-based clustering of glycosylation-related genes by RNAi-mediated gene silencing. Yamamoto-Hino M, et al. Genes Cells, 2015 Jun. PMID 25940448, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chitin synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables chitin synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chitin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
chitin synthase 2
Names
CG7464-PC
CG7464-PD
Chs2-PC
Chs2-PD
chitin Syn2
chitin synthase A
chitin-synthase
NP_001137997.2
NP_524209.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21962401..21969964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079485.4 → NP_524209.3  chitin synthase 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524209.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1NZB3, Q9VNW7
    Conserved Domains (2) summary
    cd04190
    Location:546 → 874
    Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin
    cl00456
    Location:903 → 1055
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001144525.2 → NP_001137997.2  chitin synthase 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137997.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z099, E1NZB3
    Conserved Domains (2) summary
    cd04190
    Location:545 → 873
    Chitin_synth_C; C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin
    cl00456
    Location:902 → 1054
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z099 B7Z099
Q8WQ83 Q8WQ83
Q9VNW7 Q9VNW7

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