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olf413 olf413 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40453, updated on 9-Dec-2024

Summary

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Official Symbol
olf413provided by FlyBase
Official Full Name
olf413provided by FlyBase
Primary source
FLYBASE:FBgn0037153
Locus tag
Dmel_CG12673
See related
AllianceGenome:FB:FBgn0037153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12673; CG14461; CG7495; CR33185; Dmel\CG12673; Olf413
Summary
Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; central brain primordium; dorsal ectoderm; and ganglia. Orthologous to human MOXD2P (monooxygenase DBH like 2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See olf413 in Genome Data Viewer
Location:
79C2-79D2; 3-47 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22136090..22247702)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22129190..22240802)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene male-specific opa containing gene Neighboring gene long non-coding RNA:CR45236 Neighboring gene long non-coding RNA:CR45971 Neighboring gene long non-coding RNA:CR45972 Neighboring gene long non-coding RNA:CR45035 Neighboring gene uncharacterized protein Neighboring gene RIC1 homolog Neighboring gene Dead-box-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. olf413, a putative octopamine biosynthesis pathway gene is required for negative geotactic motor function in Drosophila melanogaster. Ramya R, et al. J Genet, 2023. PMID 38073169
  2. olf413 an octopamine biogenesis pathway gene is required for axon growth and pathfinding during embryonic nervous system development in Drosophila melanogaster. Ramya R, et al. BMC Res Notes, 2024 Feb 7. PMID 38326892, Free PMC Article
  3. Identification of genetic modifiers of lifespan on a high sugar diet in the Drosophila Genetic Reference Panel. Patel SP, et al. Heliyon, 2021 Jun. PMID 34141921, Free PMC Article
  4. Signatures of Insecticide Selection in the Genome of Drosophila melanogaster. Duneau D, et al. G3 (Bethesda), 2018 Nov 6. PMID 30190420, Free PMC Article
  5. Context-dependent genetic architecture of Drosophila life span. Huang W, et al. PLoS Biol, 2020 Mar. PMID 32134916, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. olf413 an octopamine biogenesis pathway gene is required for axon growth and pathfinding during embryonic nervous system development in Drosophila melanogaster.
    Title: olf413 an octopamine biogenesis pathway gene is required for axon growth and pathfinding during embryonic nervous system development in Drosophila melanogaster.
  2. olf413, a putative octopamine biosynthesis pathway gene is required for negative geotactic motor function in Drosophila melanogaster.
    Title: olf413, a putative octopamine biosynthesis pathway gene is required for negative geotactic motor function in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables dopamine beta-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dopamine beta-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dopamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in norepinephrine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in octopamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in secretory granule membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olf413
Names
CG12673-PB
CG12673-PC
olf413-PB
olf413-PC
NP_001262204.1
NP_730711.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22136090..22247702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275275.1 → NP_001262204.1  olf413, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NP60, Q9GTU8, Q9VNV6
    UniProtKB/TrEMBL
    M9PDA4
    Conserved Domains (3) summary
    cd09631
    Location:111 → 243
    DOMON_DOH; DOMON-like domain of copper-dependent monooxygenases and related proteins
    pfam01082
    Location:282 → 407
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:438 → 583
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

  2. NM_168948.5 → NP_730711.3  olf413, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730711.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NP60, Q9GTU8, Q9VNV6
    UniProtKB/TrEMBL
    M9PDA4
    Conserved Domains (3) summary
    cd09631
    Location:111 → 243
    DOMON_DOH; DOMON-like domain of copper-dependent monooxygenases and related proteins
    pfam01082
    Location:282 → 407
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:438 → 583
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDA4 M9PDA4
Q6NP60.1 Q6NP60

Gene LinkOut

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