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ArfGAP3 ADP-ribosylation factor GTPase activating protein 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40487, updated on 4-Jan-2025

Summary

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Official Symbol
ArfGAP3provided by FlyBase
Official Full Name
ADP-ribosylation factor GTPase activating protein 3provided by FlyBase
Primary source
FLYBASE:FBgn0037182
Locus tag
Dmel_CG6838
See related
AllianceGenome:FB:FBgn0037182
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AG2; arfgap1; CG6838; dArfGAP3; Dmel\CG6838
Summary
Predicted to enable GTPase activator activity. Involved in compound eye morphogenesis. Located in cytoplasm. Colocalizes with adherens junction. Is expressed in several structures, including adult head; anlage in statu nascendi; embryonic/larval midgut; gland; and salivary gland body primordium. Orthologous to several human genes including ARFGAP2 (ARF GTPase activating protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ArfGAP3 in Genome Data Viewer
Location:
79F6-79F6; 3-47 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22714313..22717577, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22707413..22710677, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46227 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene maelstrom

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ancient complexity, opisthokont plasticity, and discovery of the 11th subfamily of Arf GAP proteins. Schlacht A, et al. Traffic, 2013 Jun. PMID 23433073, Free PMC Article
  2. ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. Xiong Y, et al. J Neurosci, 2012 Mar 14. PMID 22423108, Free PMC Article
  3. Chromatin-mediated microtubule nucleation in Drosophila syncytial embryos. Hayward D, et al. Commun Integr Biol, 2014. PMID 25053984, Free PMC Article
  4. Role for a Cindr-Arf6 axis in patterning emerging epithelia. Johnson RI, et al. Mol Biol Cell, 2011 Dec. PMID 21976699, Free PMC Article
  5. Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs. Gupta GD, et al. PLoS One, 2009 Aug 26. PMID 19707569, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPI coating of Golgi vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ADP-ribosylation factor GTPase activating protein 3
Names
ArfGAP3-PA
ArfGAP3-PB
ArfGAP3-PC
ArfGAP3-PE
ArfGAP3-PF
ArfGAP3-PG
ArfGAP3-PH
CG6838-PA
CG6838-PB
CG6838-PC
CG6838-PE
CG6838-PF
CG6838-PG
CG6838-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22714313..22717577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141152.1 → NP_649409.1  ADP-ribosylation factor GTPase activating protein 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNS2
    Related
    FBpp0078191, FBtr0078539
    Conserved Domains (1) summary
    smart00105
    Location:17 → 121
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

  2. NM_001104193.2 → NP_001097663.1  ADP-ribosylation factor GTPase activating protein 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNS2
    Conserved Domains (1) summary
    smart00105
    Location:17 → 121
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

  3. NM_001104194.2 → NP_001097664.2  ADP-ribosylation factor GTPase activating protein 3, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097664.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNX0
    Conserved Domains (1) summary
    smart00105
    Location:17 → 121
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

  4. NM_001275287.1 → NP_001262216.1  ADP-ribosylation factor GTPase activating protein 3, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262216.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGG0
    Conserved Domains (1) summary
    smart00105
    Location:17 → 121
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

  5. NM_001275288.1 → NP_001262217.1  ADP-ribosylation factor GTPase activating protein 3, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262217.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG88
    Conserved Domains (1) summary
    smart00105
    Location:17 → 121
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

  6. NM_001275289.1 → NP_001262218.1  ADP-ribosylation factor GTPase activating protein 3, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262218.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PIL3
    Conserved Domains (1) summary
    smart00105
    Location:17 → 121
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

  7. NM_168955.3 → NP_730735.1  ADP-ribosylation factor GTPase activating protein 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730735.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNS2
    Related
    FBpp0078192
    Conserved Domains (1) summary
    smart00105
    Location:17 → 121
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNX0 A8JNX0
M9PG88 M9PG88
M9PGG0 M9PGG0
M9PIL3 M9PIL3
Q9VNS2 Q9VNS2

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