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CG14450 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40490, updated on 4-Jan-2025

Summary

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Official Symbol
CG14450provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037184
Locus tag
Dmel_CG14450
See related
AllianceGenome:FB:FBgn0037184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG14450
Summary
Predicted to enable DNA polymerase processivity factor activity. Predicted to be involved in mitochondrial transcription. Predicted to be active in mitochondrial nucleoid. Is expressed in adult head. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human TEFM (transcription elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG14450 in Genome Data Viewer
Location:
80A1-80A1; 3-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22726234..22727789, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22719334..22720889, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene maelstrom Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease. Bourquard T, et al. Nat Commun, 2023 May 13. PMID 37179358, Free PMC Article
  2. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Bellen HJ, et al. Genetics, 2004 Jun. PMID 15238527, Free PMC Article
  3. Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs. Li H, et al. DNA Res, 2016 Dec. PMID 27559081, Free PMC Article
  4. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
  5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA polymerase processivity factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA polymerase processivity factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription elongation by mitochondrial RNA polymerase IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial nucleoid ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14450-PA
CG14450-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22726234..22727789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141154.4 → NP_649411.1  uncharacterized protein Dmel_CG14450, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649411.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNR9
    Related
    FBpp0078189

  2. NM_001275290.1 → NP_001262219.1  uncharacterized protein Dmel_CG14450, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262219.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDB7
    Conserved Domains (1) summary
    PLN02216
    Location:28 → 62
    PLN02216; protein SRG1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDB7 M9PDB7
Q9VNR9 Q9VNR9

Gene LinkOut

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