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EMC4 ER membrane protein complex subunit 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40505, updated on 9-Dec-2024

Summary

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Official Symbol
EMC4provided by FlyBase
Official Full Name
ER membrane protein complex subunit 4provided by FlyBase
Primary source
FLYBASE:FBgn0037199
Locus tag
Dmel_CG11137
See related
AllianceGenome:FB:FBgn0037199
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD31024; CG11137; CT31141; Dmel\CG11137; emc4
Summary
Contributes to membrane insertase activity. Involved in tail-anchored membrane protein insertion into ER membrane. Located in endomembrane system. Part of EMC complex. Is expressed in adult head; adult heart; and organism. Orthologous to human EMC4 (ER membrane protein complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See EMC4 in Genome Data Viewer
Location:
80B1-80B1; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22867175..22868243, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22860588..22861343, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ADP ribosylation factor 1 Neighboring gene antisense RNA:CR45969

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Xiong L, et al. Cell Death Differ, 2020 Feb. PMID 31263175, Free PMC Article
  2. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article
  3. Microarray analysis of juvenile hormone response in Drosophila melanogaster S2 cells. Willis DK, et al. J Insect Sci, 2010. PMID 20672983, Free PMC Article
  4. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
  5. FISH analysis of Drosophila melanogaster heterochromatin using BACs and P elements. Corradini N, et al. Chromosoma, 2003 Jul. PMID 12827380

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to membrane insertase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in tail-anchored membrane protein insertion into ER membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in endomembrane system HDA PubMed 

General protein information

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Preferred Names
ER membrane protein complex subunit 4
Names
CG11137-PA
CG11137-PB
EMC4-PA
EMC4-PB
endoplasmic reticulum membrane protein complex 4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22867175..22868243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316459.1 → NP_001303388.1  ER membrane protein complex subunit 4, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNQ3
    Conserved Domains (1) summary
    pfam06417
    Location:43 → 152
    DUF1077; Protein of unknown function (DUF1077)

  2. NM_141167.3 → NP_649424.1  ER membrane protein complex subunit 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649424.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNQ3
    Related
    FBpp0078227
    Conserved Domains (1) summary
    pfam06417
    Location:43 → 152
    DUF1077; Protein of unknown function (DUF1077)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VNQ3 Q9VNQ3

Gene LinkOut

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