alpha-Cat - alpha Catenin

Predicted to enable actin filament binding activity and beta-catenin binding activity. Involved in several processes, including apical constriction; dorsal closure, amnioserosa morphology change; and head morphogenesis. Located in adherens junction and plasma membrane. Part of catenin complex. Is expressed in several structures, including adult neuromere; epithelium; gut section; imaginal disc; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13; complex cortical dysplasia with other brain malformations; and patterned macular dystrophy 2. Orthologous to several human genes including CTNNA2 (catenin alpha 2). [provided by Alliance of Genome Resources, Nov 2024]

NCBI Orthologs

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