hkb - huckebein
Enables sequence-specific DNA binding activity and transcription corepressor binding activity. Involved in several processes, including germ cell migration; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in nucleus. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; embryonic procephalic segment; head epidermis primordium; and neuroblasts. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1K and congenital dyserythropoietic anemia type IV. Orthologous to several human genes including KLF1 (KLF transcription factor 1); KLF14 (KLF transcription factor 14); and KLF16 (KLF transcription factor 16). [provided by Alliance of Genome Resources, Dec 2024]
NCBI Orthologs
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Protein alignment
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