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CG9853 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40557, updated on 4-Jan-2025

Summary

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Official Symbol
CG9853provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0086605
Locus tag
Dmel_CG9853
See related
AllianceGenome:FB:FBgn0086605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD21829; CG41469; Dmel\CG9853; Get4
Old locus tag
CG41469; Dmel_CG41469
Summary
Predicted to be involved in protein insertion into ER membrane. Predicted to be part of BAT3 complex. Predicted to be active in cytosol. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GET4 (guided entry of tail-anchored proteins factor 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG9853 in Genome Data Viewer
Location:
82A5-82A5; 3-47.1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4398381..4402027, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (224103..227749, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46139 Neighboring gene antisense RNA:CR45999 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45187 Neighboring gene lost

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective. Wilson EL, et al. Cell Death Dis, 2024 Mar 11. PMID 38467609, Free PMC Article
  2. A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin. Sinsimer KS, et al. Development, 2011 Aug. PMID 21752933, Free PMC Article
  3. Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State. Kobayashi H, et al. Mol Cell, 2019 Jan 3. PMID 30503771
  4. The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria. Ge DT, et al. Mol Cell, 2019 Jun 6. PMID 31076285, Free PMC Article
  5. Comparative interactome analysis of α-arrestin families in human and Drosophila. Lee KT, et al. Elife, 2024 Jan 25. PMID 38270169, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into ER membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of BAT3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG9853-PA
CG9853-PB
CG9853-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4398381..4402027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300227.1 → NP_001287156.1  uncharacterized protein Dmel_CG9853, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287156.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VN19
    UniProtKB/TrEMBL
    A0A0B4LGQ8
    Conserved Domains (1) summary
    pfam04190
    Location:55 → 310
    DUF410; Protein of unknown function (DUF410)

  2. NM_001104210.1 → NP_001097680.1  uncharacterized protein Dmel_CG9853, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097680.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VN19
    UniProtKB/TrEMBL
    A0A0B4LGQ8
    Conserved Domains (1) summary
    pfam04190
    Location:55 → 310
    DUF410; Protein of unknown function (DUF410)

  3. NM_141207.5 → NP_649464.1  uncharacterized protein Dmel_CG9853, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649464.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VN19
    UniProtKB/TrEMBL
    A0A0B4LGQ8
    Related
    FBpp0078589
    Conserved Domains (1) summary
    pfam04190
    Location:55 → 310
    DUF410; Protein of unknown function (DUF410)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGQ8 A0A0B4LGQ8
Q9VN19.1 Q9VN19

Gene LinkOut

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