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srl - spargel

Predicted to enable mRNA binding activity and nuclear receptor coactivator activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of insulin receptor signaling pathway; and positive regulation of oxidative phosphorylation. Located in cytosol and nuclear speck. Is expressed in several structures, including adult gnathal ganglion; embryonic/larval midgut primordium; larval somatic muscle cell; mesoderm; and visceral mesoderm derivative. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); obesity; and type 2 diabetes mellitus. Orthologous to several human genes including PPARGC1A (PPARG coactivator 1 alpha) and PPRC1 (PPARG related coactivator 1). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa