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CG1074 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40564, updated on 9-Dec-2024

Summary

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Official Symbol
CG1074provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037250
Locus tag
Dmel_CG1074
See related
AllianceGenome:FB:FBgn0037250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.308; Dmel\CG1074
Summary
Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Predicted to be part of tRNA (m2G10) methyltransferase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gut section; larval muscle system; and trunk mesoderm. Orthologous to human TRMT11 (tRNA methyltransferase 11 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG1074 in Genome Data Viewer
Location:
82B1-82B1; 3-47.1 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4433965..4436175)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (259687..261897)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene spargel Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit a Neighboring gene antisense RNA:CR46138 Neighboring gene antisense RNA:CR44134 Neighboring gene Lipoyl(octanoyl) transferase 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myopathic lamin mutations cause reductive stress and activate the nrf2/keap-1 pathway. Dialynas G, et al. PLoS Genet, 2015 May. PMID 25996830, Free PMC Article
  2. Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. Cunha PM, et al. PLoS Genet, 2010 Jul 1. PMID 20617173, Free PMC Article
  3. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
  4. A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Lunardi A, et al. Proc Natl Acad Sci U S A, 2010 Apr 6. PMID 20308539, Free PMC Article
  5. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 4434424-4434469 mobile_element_type = transposon:INE-1{}3806

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanine(10)-N2)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m2G10) methyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1074-PA
NP_649471.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4433965..4436175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141214.5 → NP_649471.3  uncharacterized protein Dmel_CG1074 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649471.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960G1, Q9VN26
    Related
    FBpp0078565
    Conserved Domains (2) summary
    COG1041
    Location:6 → 377
    Trm11; tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]
    cl17173
    Location:190 → 367
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q960G1 Q960G1

Gene LinkOut

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