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sac sterile affecting ciliogenesis [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40568, updated on 4-Jan-2025

Summary

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Official Symbol
sacprovided by FlyBase
Official Full Name
sterile affecting ciliogenesisprovided by FlyBase
Primary source
FLYBASE:FBgn0037254
Locus tag
Dmel_CG14651
See related
AllianceGenome:FB:FBgn0037254
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14651; Dmel\CG14651
Summary
Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Involved in flagellated sperm motility. Located in sperm flagellum. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See sac in Genome Data Viewer
Location:
82B3-82B3; 3-47.1 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4480812..4484215)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (306534..309937)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43629 Neighboring gene uncharacterized protein Neighboring gene Factor interacting with poly(A) polymerase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Impact of cilia-related genes on mitochondrial dynamics during Drosophila spermatogenesis. Bauerly E, et al. Dev Biol, 2022 Feb. PMID 34822845
  2. The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control. Messina G, et al. Cells, 2022 Sep 29. PMID 36231024, Free PMC Article
  3. Structure and molecular basis of spermatid elongation in the Drosophila testis. Huang Q, et al. Open Biol, 2023 Nov. PMID 37935354, Free PMC Article
  4. A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth. Laviolette MJ, et al. Genetics, 2005 Jun. PMID 15834148, Free PMC Article
  5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sterile affecting ciliogenesis
Names
CG14651-PB
sac-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4480812..4484215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141218.3 → NP_649475.3  sterile affecting ciliogenesis [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649475.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1LZ49, Q9VN30
    Conserved Domains (1) summary
    pfam08393
    Location:904 → 1042
    DHC_N2; Dynein heavy chain, N-terminal region 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VN30 Q9VN30

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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