Nep2 Neprilysin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nep2provided by FlyBase
Official Full Name: Neprilysin 2provided by FlyBase
Primary source: FLYBASE:FBgn0027570
Locus tag: Dmel_CG9761
See related: AllianceGenome:FB:FBgn0027570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH07643; CG9761; Dmel\CG9761; DmNEP2; dNEP2; nep2; NEP2
Summary: Enables metalloendopeptidase activity. Involved in proteolysis and sperm competition. Located in extracellular space. Is expressed in several structures, including adult brain; epithelium; follicle cell; synaptic neuropil domain; and visceral trunk mesoderm derivative. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 82D2-82D2; 3-47.1 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4719458..4731878, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (545180..557600, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The NEP2 involved in middle-term memory (MTM) and long-term memory (LTM) and that their expression is required in the mushroom bodies and also in a single pair of closely connected neurons.
Title: Drosophila Neprilysins Are Involved in Middle-Term and Long-Term Memory.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c4722120-4722001 mobile_element_type = transposon:INE-1{}4487

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metallopeptidase activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISM Inferred from Sequence Model more info	PubMed
involved_in sperm competition	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neprilysin 2

Names: CG9761-PA; CG9761-PB; CG9761-PC; Nep2-PA; Nep2-PB; Nep2-PC; neprilysin-2

NP_001246914.1

EC 3.4.24.-

NP_001262260.1

EC 3.4.24.-

NP_524227.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

4719458..4731878 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275331.1 → NP_001262260.1 neprilysin 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262260.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4K692

Conserved Domains (2) summary

cd08662
Location:104 → 761

M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

COG3590
Location:92 → 763

PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
NM_079503.4 → NP_524227.1 neprilysin 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524227.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4K692

Related

FBpp0078531

Conserved Domains (2) summary

cd08662
Location:104 → 761

M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

COG3590
Location:92 → 763

PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
NM_001259985.2 → NP_001246914.1 neprilysin 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246914.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4K692, D3DMK4, Q9XZ01

Conserved Domains (1) summary

cd08662
Location:104 → 772

M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I