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ctrip circadian trip [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40596, updated on 9-Dec-2024

Summary

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Official Symbol
ctripprovided by FlyBase
Official Full Name
circadian tripprovided by FlyBase
Primary source
FLYBASE:FBgn0260794
Locus tag
Dmel_CG42574
See related
AllianceGenome:FB:FBgn0260794
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14656; CG17735; CG42574; Ctrip; CTRIP; CTRIP/TRIP12; Dmel\CG42574; TRIP12
Old locus tag
Dmel_CG14656; Dmel_CG17735
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in positive regulation of circadian rhythm and positive regulation of protein catabolic process. Predicted to be located in nucleus. Predicted to be active in nuclear speck. Is expressed in several structures, including adult head and neurosecretory neurons. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See ctrip in Genome Data Viewer
Location:
82D5-82D6; 3-47.1 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4786284..4812096, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (612006..637818, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain containing protein 39 Neighboring gene Hus1-like Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene uncharacterized protein Neighboring gene Bardet-Biedl syndrome 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of TGFβ signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12. Keyan KS, et al. Cell Death Dis, 2023 Oct 20. PMID 37863914, Free PMC Article
  2. Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless. Peschel N, et al. Curr Biol, 2009 Feb 10. PMID 19185492
  3. Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins. Greenblatt EJ, et al. Science, 2018 Aug 17. PMID 30115809, Free PMC Article
  4. An in vivo strategy for knockdown of circular RNAs. Pamudurti NR, et al. Cell Discov, 2020. PMID 32818061, Free PMC Article
  5. The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation. Aravind L. Trends Biochem Sci, 2001 May. PMID 11343911

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identify a clock function for the circadian trip gene, which encodes a HECT-domain E3 ubiquitin ligase.
    Title: The E3 ubiquitin ligase CTRIP controls CLOCK levels and PERIOD oscillations in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
circadian trip
Names
CG42574-PA
CG42574-PB
CG42574-PC
CG42574-PE
CG42574-PF
CG42574-PH
CG42574-PI
CG42574-PJ
CG42574-PK
CG42574-PL
CG42574-PM
ctrip-PA
ctrip-PB
ctrip-PC
ctrip-PE
ctrip-PF
ctrip-PH
ctrip-PI
ctrip-PJ
ctrip-PK
ctrip-PL
ctrip-PM

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4786284..4812096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202243.3 → NP_001189172.2  circadian trip, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189172.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD62, F6M9W1
    Conserved Domains (3) summary
    smart00678
    Location:1005 → 1077
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    pfam15814
    Location:1581 → 1671
    FAM199X; Protein family FAM199X
    cl00077
    Location:2414 → 2734
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  2. NM_001300233.1 → NP_001287162.1  circadian trip, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGQ5, F6M9W2
    Conserved Domains (3) summary
    smart00678
    Location:1170 → 1242
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    pfam15814
    Location:1746 → 1836
    FAM199X; Protein family FAM199X
    cl00077
    Location:2579 → 2899
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  3. NM_001202246.3 → NP_001189175.2  circadian trip, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189175.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JCW5, F6M9W2
    Conserved Domains (3) summary
    smart00678
    Location:1198 → 1270
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    pfam15814
    Location:1774 → 1864
    FAM199X; Protein family FAM199X
    cl00077
    Location:2607 → 2927
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  4. NM_001300234.1 → NP_001287163.1  circadian trip, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287163.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHQ4, F6M9W1
    Conserved Domains (3) summary
    smart00678
    Location:977 → 1049
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    COG5064
    Location:655 → 880
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    cl27008
    Location:2386 → 2706
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  5. NM_001202247.2 → NP_001189176.1  circadian trip, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189176.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDB5, F6M9W1
    Conserved Domains (3) summary
    smart00678
    Location:1006 → 1078
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    pfam15814
    Location:1582 → 1672
    FAM199X; Protein family FAM199X
    cl00077
    Location:2415 → 2735
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  6. NM_001202244.2 → NP_001189173.1  circadian trip, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189173.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JCV6, F6M9W2
    Conserved Domains (3) summary
    smart00678
    Location:1199 → 1271
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    pfam15814
    Location:1775 → 1865
    FAM199X; Protein family FAM199X
    cl00077
    Location:2608 → 2928
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  7. NM_001202241.2 → NP_001189170.1  circadian trip, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189170.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F6M9W0, Q9VN58
    Conserved Domains (4) summary
    smart00678
    Location:1409 → 1481
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    pfam04554
    Location:688 → 731
    Extensin_2; Extensin-like region
    pfam15814
    Location:1985 → 2074
    FAM199X; Protein family FAM199X
    cl00077
    Location:2818 → 3138
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  8. NM_001202242.2 → NP_001189171.1  circadian trip, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189171.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDB5, F6M9W1
    Conserved Domains (3) summary
    smart00678
    Location:1006 → 1078
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    pfam15814
    Location:1582 → 1672
    FAM199X; Protein family FAM199X
    cl00077
    Location:2415 → 2735
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  9. NM_001300232.1 → NP_001287161.1  circadian trip, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGR2, F6M9W0
    Conserved Domains (4) summary
    smart00678
    Location:1380 → 1452
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    pfam04554
    Location:688 → 731
    Extensin_2; Extensin-like region
    pfam15814
    Location:1956 → 2045
    FAM199X; Protein family FAM199X
    cl00077
    Location:2789 → 3109
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  10. NM_001202245.3 → NP_001189174.1  circadian trip, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189174.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDA1, F6M9W0
    Conserved Domains (4) summary
    smart00678
    Location:1408 → 1480
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    pfam04554
    Location:688 → 731
    Extensin_2; Extensin-like region
    pfam15814
    Location:1984 → 2073
    FAM199X; Protein family FAM199X
    cl00077
    Location:2817 → 3137
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  11. NM_141239.5 → NP_649496.3  circadian trip, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649496.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    F6M9W0, Q9VN58
    Conserved Domains (4) summary
    smart00678
    Location:1409 → 1481
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    pfam04554
    Location:688 → 731
    Extensin_2; Extensin-like region
    pfam15814
    Location:1985 → 2074
    FAM199X; Protein family FAM199X
    cl00077
    Location:2818 → 3138
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JCV6 A0A0B4JCV6
A0A0B4JCW5 A0A0B4JCW5
A0A0B4JD62 A0A0B4JD62
A0A0B4JDA1 A0A0B4JDA1
A0A0B4JDB5 A0A0B4JDB5
A0A0B4LGQ5 A0A0B4LGQ5
A0A0B4LGR2 A0A0B4LGR2
A0A0B4LHQ4 A0A0B4LHQ4
Q9VN58 Q9VN58

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