Notch4 notch receptor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Notch4provided by RGD
Official Full Name: notch receptor 4provided by RGD
Primary source: RGD:1303282
See related: EnsemblRapid:ENSRNOG00000000442 AllianceGenome:RGD:1303282
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; Notch binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in endothelial cell morphogenesis and luteolysis. Predicted to be located in cell surface; cytoplasmic vesicle; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (notch receptor 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Lung (RPKM 59.6), Heart (RPKM 41.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4164969..4189072, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4160362..4184466, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (4329794..4353868)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension.
Title: Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension.
mild hypothermia inhibits Notch 3 and Notch 4 activation and seizure after stroke in the rat model
Title: Mild hypothermia inhibits the Notch 3 and Notch 4 activation and seizure after stroke in the rat model.
An increasing wall shear stress may contribute to the angiogenesis of arteriovenous malformations by activation of Notch signaling.
Title: Notch1 and 4 signaling responds to an increasing vascular wall shear stress in a rat model of arteriovenous malformations.
The delta-Notch signaling pathway may be active during vein graft adaptation.
Title: Age-related Notch-4 quiescence is associated with altered wall remodeling during vein graft adaptation.
Data suggest that NOTCH1, NOTCH4, and DLL4 are expressed in nuclei of small/large luteal cells of corpora lutea (CL) from pregnant rats and that luteolytic hormone PGF2alpha decreases the CL mRNA and protein expression of these NOTCH family members.
Title: Role of the DLL4-NOTCH system in PGF2alpha-induced luteolysis in the pregnant rat.
The implication of a dysregulated Notch pathway to endothelial and vascular dysfunction.
Title: Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction.
investigated regulation of the Notch4 pathway on cardiac allograft arteriosclerosis and further examined its implication in endothelial cell dysfunction
Title: Impaired Notch4 activity elicits endothelial cell activation and apoptosis: implication for transplant arteriosclerosis.

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General gene information

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Markers

D20Yum63 (e-PCR)
- UniSTS:526117

Notch4 (e-PCR), detects polymorphism
- UniSTS:465466

UniSTS:465467 (e-PCR)
- UniSTS:465467

Notch4 (e-PCR), detects polymorphism
- UniSTS:465467

BE113482 (e-PCR)
- UniSTS:246670

AA799611 (e-PCR)
- UniSTS:260590

RH139089 (e-PCR)
- UniSTS:221175

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelial cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in luteolysis	IEP Inferred from Expression Pattern more info	PubMed
involved_in mammary gland development	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of a branching structure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion molecule production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of aorta morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within venous blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neurogenic locus notch homolog protein 4

Names: notch 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002827.1 → NP_001002827.1 neurogenic locus notch homolog protein 4 precursor

See identical proteins and their annotated locations for NP_001002827.1

Status: PROVISIONAL

Source sequence(s)

BX883044

UniProtKB/TrEMBL

A6KTE6, A6KTE7, F7EQS6, Q6MG89

Related

ENSRNOP00000000513.4, ENSRNOT00000000513.6

Conserved Domains (8) summary

cd00054
Location:429 → 470

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00204
Location:1625 → 1732

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00066
Location:1245 → 1281

Notch; LNR domain

pfam06816
Location:1291 → 1337

NOD; NOTCH protein

pfam07645
Location:191 → 224

EGF_CA; Calcium-binding EGF domain

pfam07684
Location:1376 → 1415

NODP; NOTCH protein

pfam12796
Location:1630 → 1723

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1626 → 1656

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

4164969..4189072 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098929.1 → XP_038954857.1 neurogenic locus notch homolog protein 4 isoform X4

Conserved Domains (9) summary

smart00004
Location:771 → 809

NL; Domain found in Notch and Lin-12

COG0666
Location:1205 → 1387

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00054
Location:116 → 152

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00045
Location:1194 → 1224

ANK; ANK repeat [structural motif]

pfam00008
Location:298 → 328

EGF; EGF-like domain

pfam00066
Location:819 → 848

Notch; LNR domain

pfam06816
Location:859 → 908

NOD; NOTCH protein

pfam12796
Location:1198 → 1291

Ank_2; Ankyrin repeats (3 copies)

cd21705
Location:1004 → 1079

JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
XM_039098927.1 → XP_038954855.1 neurogenic locus notch homolog protein 4 isoform X2

Conserved Domains (10) summary

smart00004
Location:779 → 817

NL; Domain found in Notch and Lin-12

COG0666
Location:1213 → 1395

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

PRK07003
Location:10 → 183

PRK07003; DNA polymerase III subunit gamma/tau

cd00054
Location:542 → 576

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00045
Location:1202 → 1232

ANK; ANK repeat [structural motif]

pfam00008
Location:306 → 336

EGF; EGF-like domain

pfam00066
Location:827 → 856

Notch; LNR domain

pfam06816
Location:867 → 916

NOD; NOTCH protein

pfam12796
Location:1206 → 1299

Ank_2; Ankyrin repeats (3 copies)

cd21705
Location:1012 → 1087

JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
XM_039098930.2 → XP_038954858.1 neurogenic locus notch homolog protein 4 isoform X5

Conserved Domains (9) summary

smart00004
Location:736 → 774

NL; Domain found in Notch and Lin-12

COG0666
Location:1170 → 1352

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00054
Location:499 → 533

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00045
Location:1159 → 1189

ANK; ANK repeat [structural motif]

pfam00008
Location:263 → 293

EGF; EGF-like domain

pfam00066
Location:784 → 813

Notch; LNR domain

pfam06816
Location:824 → 873

NOD; NOTCH protein

pfam12796
Location:1163 → 1256

Ank_2; Ankyrin repeats (3 copies)

cd21705
Location:969 → 1044

JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
XM_039098926.2 → XP_038954854.1 neurogenic locus notch homolog protein 4 isoform X1

UniProtKB/TrEMBL

A6KTE7

Conserved Domains (8) summary

smart00004
Location:1203 → 1241

NL; Domain found in Notch and Lin-12

cd00054
Location:429 → 470

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00045
Location:1626 → 1656

ANK; ANK repeat [structural motif]

pfam07645
Location:191 → 224

EGF_CA; Calcium-binding EGF domain

pfam00066
Location:1251 → 1280

Notch; LNR domain

pfam06816
Location:1291 → 1340

NOD; NOTCH protein

pfam12796
Location:1630 → 1723

Ank_2; Ankyrin repeats (3 copies)

cd21705
Location:1436 → 1511

JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
XM_039098928.2 → XP_038954856.1 neurogenic locus notch homolog protein 4 isoform X3

UniProtKB/TrEMBL

A6KTE7

Conserved Domains (6) summary

smart00004
Location:1203 → 1241

NL; Domain found in Notch and Lin-12

cd00054
Location:429 → 470

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:191 → 224

EGF_CA; Calcium-binding EGF domain

pfam00066
Location:1251 → 1280

Notch; LNR domain

pfam06816
Location:1291 → 1340

NOD; NOTCH protein

cd21705
Location:1436 → 1511

JMTM_Notch4; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
XM_039098931.2 → XP_038954859.1 neurogenic locus notch homolog protein 4 isoform X6

UniProtKB/TrEMBL

A6KTE8

Conserved Domains (5) summary

smart00004
Location:1203 → 1241

NL; Domain found in Notch and Lin-12

cd00054
Location:429 → 470

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam07645
Location:191 → 224

EGF_CA; Calcium-binding EGF domain

pfam00066
Location:1251 → 1280

Notch; LNR domain

pfam06816
Location:1291 → 1340

NOD; NOTCH protein