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Egfl8 EGF-like-domain, multiple 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 406166, updated on 27-Nov-2024

Summary

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Official Symbol
Egfl8provided by RGD
Official Full Name
EGF-like-domain, multiple 8provided by RGD
Primary source
RGD:1549706
See related
EnsemblRapid:ENSRNOG00000000436 AllianceGenome:RGD:1549706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ng3
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in vasculogenesis. Predicted to be active in cell surface and extracellular region. Orthologous to human EGFL8 (EGF like domain multiple 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 113.5), Thymus (RPKM 72.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Egfl8 in Genome Data Viewer
Location:
20p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4137531..4140632)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4132930..4136024)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4378205..4380959, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase like Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene ring finger protein 5 Neighboring gene advanced glycosylation end product-specific receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Fitch MJ, et al. Dev Dyn, 2004 Jun. PMID 15162510, Free PMC Article
  2. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC156528

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
NOT involved_in in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vasculogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
epidermal growth factor-like protein 8
Names
EGF-like domain 8
EGF-like domain-containing protein 8
EGF-like protein 8
multiple EGF-like domain protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004070.3 → NP_001004070.1  epidermal growth factor-like protein 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001004070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform.
    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/Swiss-Prot
    A0JPK1, Q6MG84
    UniProtKB/TrEMBL
    A0A8I6AMC1, A6KTH4, A6KTH6
    Related
    ENSRNOP00000000499.6, ENSRNOT00000000499.8
    Conserved Domains (3) summary
    smart00179
    Location:143 → 170
    EGF_CA; Calcium-binding EGF-like domain
    pfam07546
    Location:36 → 100
    EMI; EMI domain
    cl00057
    Location:108 → 181
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. NM_001165880.2 → NP_001159352.1  epidermal growth factor-like protein 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001159352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region compared to variant 1. The resulting protein (isoform 2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A8I6AMC1, A6KTH4, A6KTH7
    Conserved Domains (3) summary
    smart00179
    Location:143 → 170
    EGF_CA; Calcium-binding EGF-like domain
    pfam07546
    Location:36 → 100
    EMI; EMI domain
    cl00057
    Location:108 → 181
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4137531..4140632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279354.1 → XP_063135424.1  epidermal growth factor-like protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A0JPK1, Q6MG84
    UniProtKB/TrEMBL
    A6KTH6

  2. XM_063279353.1 → XP_063135423.1  epidermal growth factor-like protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A0JPK1, Q6MG84
    UniProtKB/TrEMBL
    A6KTH6

  3. XM_039098934.2 → XP_038954862.1  epidermal growth factor-like protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A0JPK1, Q6MG84
    UniProtKB/TrEMBL
    A0A8I6AMC1, A6KTH4, A6KTH6
    Conserved Domains (3) summary
    smart00179
    Location:143 → 170
    EGF_CA; Calcium-binding EGF-like domain
    pfam07546
    Location:36 → 100
    EMI; EMI domain
    cl00057
    Location:108 → 181
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. XM_006255978.5 → XP_006256040.1  epidermal growth factor-like protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006256040.1

    UniProtKB/Swiss-Prot
    A0JPK1, Q6MG84
    UniProtKB/TrEMBL
    A0A8I6AMC1, A6KTH4, A6KTH6
    Conserved Domains (3) summary
    smart00179
    Location:143 → 170
    EGF_CA; Calcium-binding EGF-like domain
    pfam07546
    Location:36 → 100
    EMI; EMI domain
    cl00057
    Location:108 → 181
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  5. XM_039098935.2 → XP_038954863.1  epidermal growth factor-like protein 8 isoform X1

    UniProtKB/Swiss-Prot
    A0JPK1, Q6MG84
    UniProtKB/TrEMBL
    A0A8I6AMC1, A6KTH4, A6KTH6
    Conserved Domains (3) summary
    smart00179
    Location:143 → 170
    EGF_CA; Calcium-binding EGF-like domain
    pfam07546
    Location:36 → 100
    EMI; EMI domain
    cl00057
    Location:108 → 181
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MG84.1 GenPept UniProtKB/Swiss-Prot:Q6MG84

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