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grb2b - growth factor receptor-bound protein 2b

Predicted to enable epidermal growth factor receptor binding activity and phosphotyrosine residue binding activity. Acts upstream of or within lymphangiogenesis. Predicted to be located in Golgi apparatus and endosome. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Is expressed in central nervous system and trigeminal placode. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa