Hph - HIF prolyl hydroxylase

Enables peptidyl-proline dioxygenase activity. Involved in cellular response to hypoxia; positive regulation of cell growth; and protein export from nucleus. Located in nucleoplasm. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; posterior endoderm; and ventral ectoderm. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to several human genes including EGLN2 (egl-9 family hypoxia inducible factor 2). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

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