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rcc2 regulator of chromosome condensation 2 [ Danio rerio (zebrafish) ]

Gene ID: 406455, updated on 4-Jan-2025

Summary

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Official Symbol
rcc2provided by ZNC
Official Full Name
regulator of chromosome condensation 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2213
See related
Ensembl:ENSDARG00000011510 AllianceGenome:ZFIN:ZDB-GENE-040426-2213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
td-60; zgc:77115; wu:fb36a03
Summary
Predicted to enable small GTPase binding activity. Involved in neural crest cell migration. Predicted to be located in several cellular components, including chromosome, centromeric region; midbody; and spindle. Predicted to be active in membrane. Orthologous to human RCC2 (regulator of chromosome condensation 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See rcc2 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (21521508..21535006, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (21594468..21608455, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene ring finger protein 207b Neighboring gene Rho guanine nucleotide exchange factor (GEF) 10-like b Neighboring gene immunoglobin superfamily, member 21b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Frøyset AK, et al. Sci Rep, 2016 Jul 12. PMID 27404450, Free PMC Article
  2. Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. Williamson RC, et al. J Cell Sci, 2014 Oct 1. PMID 25074804, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome passenger complex localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein RCC2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213176.1 → NP_998341.1  protein RCC2 homolog

    Status: PROVISIONAL

    Source sequence(s)
    BC066628
    UniProtKB/Swiss-Prot
    Q6NYE2
    Related
    ENSDARP00000004838.7, ENSDART00000010647.9
    Conserved Domains (2) summary
    pfam00415
    Location:141 → 190
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:121 → 154
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    21521508..21535006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162162.5 → XP_005162219.1  protein RCC2 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q6NYE2
    Conserved Domains (2) summary
    pfam00415
    Location:141 → 190
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:121 → 154
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395145.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    38046..51544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYE2.1 GenPept UniProtKB/Swiss-Prot:Q6NYE2

Gene LinkOut

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