ksr kinase suppressor of ras [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ksrprovided by FlyBase
Official Full Name: kinase suppressor of rasprovided by FlyBase
Primary source: FLYBASE:FBgn0015402
Locus tag: Dmel_CG2899
See related: AllianceGenome:FB:FBgn0015402
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2899; dKsr; Dmel\CG2899; EC3-1; EK3-1; Ksr; KSR; Ksr-1; KSR-1; l(3)j5E2; SR3-1
Summary: Enables MAP-kinase scaffold activity; kinase binding activity; and protein kinase activator activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; open tracheal system development; and positive regulation of intracellular signal transduction. Predicted to be active in cytoplasm. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in breast adenocarcinoma. Orthologous to several human genes including KSR1 (kinase suppressor of ras 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 83A5-83A5; 3-47.5 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5478390..5483906, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1304112..1309628, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the atypical C1 domain, the CC-SAM domain is required to target KSR-1 to the plasma membrane.
Title: A CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane.
KSR is a scaffold required for activation of the ERK/MAPK module.
Title: KSR is a scaffold required for activation of the ERK/MAPK module.
Review discusses the possibility that KSR, a RAF-like protein, does not solely act as a scaffold, but directly induces RAF catalytic function by a kinase-independent mechanism apparently shared by RAF-like proteins.
Title: KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP-kinase scaffold activity	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in R7 cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in R7 cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterior/posterior axis specification, embryo	TAS Traceable Author Statement more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Ras protein signal transduction	HGI more info	PubMed
involved_in positive regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sevenless signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in torso signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal outgrowth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinase suppressor of ras

Names: CG2899-PA; CG2899-PB; CG2899-PC; CG2899-PD; kinase suppressor of Ras; kinase suppressor of Ras85D; ksr-PA; ksr-PB; ksr-PC; ksr-PD; suppressor of Ras1 3-1

NP_001287177.1

EC 2.7.11.1

NP_001287178.1

EC 2.7.11.1

NP_001287179.1

EC 2.7.11.1

NP_524236.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

5478390..5483906 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300249.1 → NP_001287178.1 kinase suppressor of ras, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287178.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24170, Q24171, Q8I0R4, Q8ISD7, Q8ISD8

Conserved Domains (4) summary

cd14063
Location:678 → 946

PK_KSR; Pseudokinase domain of Kinase Suppressor of Ras

pfam00130
Location:368 → 419

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam07714
Location:679 → 940

Pkinase_Tyr; Protein tyrosine kinase

pfam13543
Location:33 → 166

KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
NM_001300248.1 → NP_001287177.1 kinase suppressor of ras, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287177.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24170, Q24171, Q8I0R4, Q8ISD7, Q8ISD8

Conserved Domains (4) summary

cd14063
Location:678 → 946

PK_KSR; Pseudokinase domain of Kinase Suppressor of Ras

pfam00130
Location:368 → 419

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam07714
Location:679 → 940

Pkinase_Tyr; Protein tyrosine kinase

pfam13543
Location:33 → 166

KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
NM_079512.3 → NP_524236.2 kinase suppressor of ras, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524236.2

Status: REVIEWED

UniProtKB/TrEMBL

Q24170, Q24171, Q8I0R4, Q8ISD7, Q8ISD8

Related

FBpp0078413

Conserved Domains (4) summary

cd14063
Location:678 → 946

PK_KSR; Pseudokinase domain of Kinase Suppressor of Ras

pfam00130
Location:368 → 419

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam07714
Location:679 → 940

Pkinase_Tyr; Protein tyrosine kinase

pfam13543
Location:33 → 166

KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
NM_001300250.1 → NP_001287179.1 kinase suppressor of ras, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287179.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24170, Q24171, Q8I0R4, Q8ISD7, Q8ISD8

Conserved Domains (4) summary

cd14063
Location:678 → 946

PK_KSR; Pseudokinase domain of Kinase Suppressor of Ras

pfam00130
Location:368 → 419

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam07714
Location:679 → 940

Pkinase_Tyr; Protein tyrosine kinase

pfam13543
Location:33 → 166

KSR1-SAM; SAM like domain present in kinase suppressor RAS 1