prxl2b peroxiredoxin like 2B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prxl2bprovided by ZNC
Official Full Name: peroxiredoxin like 2Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2556
See related: Ensembl:ENSDARG00000029795 AllianceGenome:ZFIN:ZDB-GENE-040426-2556
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: selu3; fam213b; sb:cb782; zgc:85644; wu:fc33a02
Summary: Predicted to enable prostaglandin F synthase activity. Predicted to be involved in prostaglandin biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process and prostaglandin metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in gut and pronephric duct. Orthologous to human PRXL2B (peroxiredoxin like 2B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (40622366..40647166, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (40358221..40383021, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	ISS Inferred from Sequence or Structural Similarity more info
enables prostaglandin F synthase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostamide/prostaglandin F synthase

Names: family with sequence similarity 213, member B; prostamide/PG F synthase; prostamide/PGF synthase; prxl2

NP_998478.1

EC 1.11.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213313.1 → NP_998478.1 prostamide/prostaglandin F synthase

See identical proteins and their annotated locations for NP_998478.1

Status: PROVISIONAL

Source sequence(s)

BC068342

UniProtKB/Swiss-Prot

Q6NV24

Related

ENSDARP00000113812.1, ENSDART00000147264.4

Conserved Domains (1) summary

cd02970
Location:17 → 167

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...