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ppt1 palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) [ Danio rerio (zebrafish) ]

Gene ID: 406648, updated on 4-Jan-2025

Summary

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Official Symbol
ppt1provided by ZNC
Official Full Name
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2653
See related
Ensembl:ENSDARG00000039980 AllianceGenome:ZFIN:ZDB-GENE-040426-2653
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63969; wu:fj17f04
Summary
Predicted to enable long-chain fatty acyl-CoA hydrolase activity and palmitoyl-(protein) hydrolase activity. Predicted to be involved in endocytosis and nervous system development. Predicted to be active in extracellular region and lysosome. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Orthologous to human PPT1 (palmitoyl-protein thioesterase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ppt1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (43740697..43757488, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (44145100..44161891, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene KIAA0319-like Neighboring gene CAP, adenylate cyclase-associated protein 1 (yeast) Neighboring gene si:ch1073-513e17.1 Neighboring gene ribosomal protein L11 Neighboring gene kelch-like family member 43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Pilot Single Cell Analysis of the Zebrafish Embryo Cellular Responses to Uropathogenic Escherichia coli Infection. Rawson A, et al. Pathog Immun, 2022. PMID 35178490, Free PMC Article
  2. An osteosarcoma zebrafish model implicates Mmp-19 and Ets-1 as well as reduced host immune response in angiogenesis and migration. Mohseny AB, et al. J Pathol, 2012 Jun. PMID 22297719
  3. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Takashima S, et al. Mol Genet Metab, 2021 Jul. PMID 34016526
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
palmitoyl-protein thioesterase 1
NP_998504.1
XP_005159823.1
XP_005159824.1
XP_017207710.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213339.1 → NP_998504.1  palmitoyl-protein thioesterase 1 precursor

    See identical proteins and their annotated locations for NP_998504.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053174
    UniProtKB/TrEMBL
    Q7T3C4
    Related
    ENSDARP00000058490.5, ENSDART00000058491.7
    Conserved Domains (1) summary
    cl21494
    Location:30 → 302
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    43740697..43757488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159766.4 → XP_005159823.1  palmitoyl-protein thioesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_005159823.1

    UniProtKB/TrEMBL
    A0A8M6YTV8, F1R8J6
    Conserved Domains (1) summary
    cl21494
    Location:30 → 302
    Abhydrolase; alpha/beta hydrolases

  2. XM_005159767.4 → XP_005159824.1  palmitoyl-protein thioesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_005159824.1

    UniProtKB/TrEMBL
    A0A8M6YTV8, F1R8J6
    Conserved Domains (1) summary
    cl21494
    Location:30 → 302
    Abhydrolase; alpha/beta hydrolases

  3. XM_017352221.3 → XP_017207710.1  palmitoyl-protein thioesterase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6YTV8, F1R8J6
    Related
    ENSDARP00000139466.1, ENSDART00000171806.3
    Conserved Domains (1) summary
    cl21494
    Location:30 → 302
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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