cnn2 calponin 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cnn2provided by ZNC
Official Full Name: calponin 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-542
See related: Ensembl:ENSDARG00000035858 AllianceGenome:ZFIN:ZDB-GENE-030131-542
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wz2414; zgc:65794; wu:fb36d03; wu:fb93a05
Summary: Predicted to enable actin binding activity and calmodulin binding activity. Acts upstream of or within regulation of MAPK cascade; regulation of blood vessel endothelial cell migration; and response to steroid hormone. Is expressed in several structures, including central nervous system; digestive system; mesoderm; periderm; and vasculature. Orthologous to human CNN2 (calponin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (24548252..24554359, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (24892601..24898672, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plays an important role in the migration of endothelial cells both in vivo and in vitro; its expression is critical for proper vascular development.
Title: A critical role for calponin 2 in vascular development.

Submit: New GeneRIF Correction

General gene information

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Markers

fb93a05.x1 (e-PCR)
- UniSTS:187656

fb36d03.x1 (e-PCR)
- UniSTS:190473

fb36d03 (e-PCR)
- UniSTS:187109

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actomyosin structure organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: calponin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213349.1 → NP_998514.1 calponin-2

See identical proteins and their annotated locations for NP_998514.1

Status: PROVISIONAL

Source sequence(s)

BC059802

UniProtKB/TrEMBL

Q6PBA5

Related

ENSDARP00000052060.5, ENSDART00000052061.6

Conserved Domains (3) summary

COG5199
Location:17 → 189

SCP1; Calponin [Cytoskeleton]

pfam00307
Location:28 → 126

CH; Calponin homology (CH) domain

pfam00402
Location:165 → 188

Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

24548252..24554359 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021479618.2 → XP_021335293.1 calponin-2 isoform X1

UniProtKB/TrEMBL

A0A8M9Q784

Conserved Domains (2) summary

pfam00307
Location:27 → 129

CH; Calponin homology (CH) domain

pfam00402
Location:195 → 218

Calponin; Calponin family repeat