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eif4a2 eukaryotic translation initiation factor 4A2 [ Danio rerio (zebrafish) ]

Gene ID: 406760, updated on 4-Jan-2025

Summary

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Official Symbol
eif4a2provided by ZNC
Official Full Name
eukaryotic translation initiation factor 4A2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2802
See related
Ensembl:ENSDARG00000016477 AllianceGenome:ZFIN:ZDB-GENE-040426-2802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63783; wu:fd50g11
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to act upstream of or within translational initiation. Is expressed in several structures, including alar plate midbrain region; head; immature eye; midbrain; and segmental plate. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See eif4a2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (7715792..7727247)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (7917787..7929243)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene wu:fc46h12 Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) Neighboring gene small nucleolar RNA SNORD2 Neighboring gene small nucleolar RNA SNORD2 Neighboring gene small nucleolar RNA SNORA81 Neighboring gene small nucleolar RNA SNORA81 Neighboring gene small nucleolar RNA SNORD2 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5b Neighboring gene TBL1X/Y related 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets. Gangras P, et al. PLoS Genet, 2020 Jun. PMID 32502192, Free PMC Article
  2. Patterns of alternative splicing in response to cold acclimation in fish. Healy TM, et al. J Exp Biol, 2019 Mar 7. PMID 30692167
  3. Phylogenetic and developmental analyses indicate complex functions of calcium-activated potassium channels in zebrafish embryonic development. Silic MR, et al. Dev Dyn, 2021 Oct. PMID 33728688, Free PMC Article
  4. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic initiation factor 4A-II
Names
eukaryotic translation initiation factor 4A
NP_998616.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213451.2 → NP_998616.2  eukaryotic initiation factor 4A-II

    Status: VALIDATED

    Source sequence(s)
    DT067300, DT072464, EH471406, EH593311
    UniProtKB/TrEMBL
    A0A8M1PH45, F1R166
    Related
    ENSDARP00000104653.2, ENSDART00000130781.4
    Conserved Domains (1) summary
    PTZ00424
    Location:25 → 411
    PTZ00424; helicase 45; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    7715792..7727247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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