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uba3 ubiquitin-like modifier activating enzyme 3 [ Danio rerio (zebrafish) ]

Gene ID: 406776, updated on 4-Jan-2025

Summary

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Official Symbol
uba3provided by ZNC
Official Full Name
ubiquitin-like modifier activating enzyme 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2825
See related
Ensembl:ENSDARG00000057987 AllianceGenome:ZFIN:ZDB-GENE-040426-2825
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ube1c; zgc:55528; wu:fb75e04; wu:fc37b11
Summary
Predicted to enable NEDD8 activating enzyme activity. Predicted to be involved in protein neddylation. Predicted to be active in cytoplasm and nucleus. Is expressed in inner ear. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See uba3 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (17785182..17803071, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (17650064..17668502, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase Neighboring gene TATA element modulatory factor 1 Neighboring gene E3 SUMO-protein ligase ZBED1-like Neighboring gene uncharacterized LOC103911822

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative transcriptome analysis of auditory OC-1 cells and zebrafish inner ear tissues in the absence of human OSBPL2 orthologues. Shi H, et al. Biochem Biophys Res Commun, 2020 Jan 1. PMID 31629475
  2. Insights into the evolution of the ISG15 and UBA7 system. Liu S, et al. Genomics, 2022 Mar. PMID 35134494
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NEDD8 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NEDD8 activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein neddylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein neddylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NEDD8-activating enzyme E1 catalytic subunit
Names
NEDD8-activating enzyme E1C
ubiquitin-activating enzyme 3
ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)
NP_998632.1
XP_005155859.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213467.1 → NP_998632.1  NEDD8-activating enzyme E1 catalytic subunit

    See identical proteins and their annotated locations for NP_998632.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045372
    UniProtKB/Swiss-Prot
    Q7ZVX6
    UniProtKB/TrEMBL
    B2GSP4
    Related
    ENSDARP00000075198.4, ENSDART00000080752.7
    Conserved Domains (3) summary
    cd01488
    Location:70 → 367
    Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:66 → 240
    ThiF; ThiF family
    pfam08825
    Location:375 → 460
    E2_bind; E2 binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    17785182..17803071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155802.5 → XP_005155859.1  NEDD8-activating enzyme E1 catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A0A8M2B283
    Conserved Domains (3) summary
    cd01488
    Location:57 → 354
    Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:53 → 227
    ThiF; ThiF family
    pfam08825
    Location:362 → 447
    E2_bind; E2 binding domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394813.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    139885..158743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZVX6.1 GenPept UniProtKB/Swiss-Prot:Q7ZVX6

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