gnb1b guanine nucleotide binding protein (G protein), beta polypeptide 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnb1bprovided by ZNC
Official Full Name: guanine nucleotide binding protein (G protein), beta polypeptide 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2855
See related: Ensembl:ENSDARG00000104372 AllianceGenome:ZFIN:ZDB-GENE-040426-2855
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: GNB1x; gnb1l; fb39f01; zgc:55774; wu:fb39f01; wu:fb98e06; wu:fj09d12
Summary: Predicted to enable signaling receptor complex adaptor activity. Acts upstream of or within positive regulation of neutrophil migration and posterior lateral line neuromast primordium migration. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in blastomere; female organism; head; and lateral line system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant intellectual developmental disorder 42; congestive heart failure; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (53304977..53334159, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (53304598..53333815, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb39f01 (e-PCR)
- UniSTS:187179

fb98e06.x1 (e-PCR)
- UniSTS:203617

fj32d10.y1 (e-PCR)
- UniSTS:199070

fb39f01.x1 (e-PCR)
- UniSTS:203190

fj09d12.x1 (e-PCR)
- UniSTS:188410

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of neutrophil migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanine nucleotide binding protein (G protein), beta polypeptide 1b

Names: guanine nucleotide binding protein (G protein), beta polypeptide 1, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213481.1 → NP_998646.1 guanine nucleotide binding protein (G protein), beta polypeptide 1b

See identical proteins and their annotated locations for NP_998646.1

Status: PROVISIONAL

Source sequence(s)

BC044482

UniProtKB/TrEMBL

A7YYJ4, Q803H5

Related

ENSDARP00000133655.1, ENSDART00000172465.2

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

53304977..53334159 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009302713.3 → XP_009300988.1 guanine nucleotide binding protein (G protein), beta polypeptide 1b isoform X1

See identical proteins and their annotated locations for XP_009300988.1

UniProtKB/TrEMBL

A7YYJ4, Q803H5

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]