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Sec23 Secretory 23 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40694, updated on 9-Dec-2024

Summary

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Official Symbol
Sec23provided by FlyBase
Official Full Name
Secretory 23provided by FlyBase
Primary source
FLYBASE:FBgn0262125
Locus tag
Dmel_CG1250
See related
AllianceGenome:FB:FBgn0262125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1250; COPII; dar2; Dmel\CG1250; dsec23; dSec23; dsec23p; dSec23p; hau; Hau; sec23; SEC23; Sec23A; Sec23p
Summary
Predicted to enable GTPase activator activity. Involved in several processes, including chitin-based larval cuticle pattern formation; protein localization to cell surface; and secretion by cell. Acts upstream of with a positive effect on chitin-based cuticle development and lumen formation, open tracheal system. Located in Golgi stack and endoplasmic reticulum exit site. Part of COPII vesicle coat. Is expressed in several structures, including adult head; embryonic proventriculus inner layer; gland; gut section; and mesoderm. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Orthologous to several human genes including SEC23B (SEC23 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Sec23 in Genome Data Viewer
Location:
83B7-83B8; 3-47.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5649065..5652629)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1474787..1478351)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Metastasis associated 1-like Neighboring gene ethanol sensitive with low memory Neighboring gene Mediator complex subunit 27 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cis-Golgi Drosophila GMAP has a role in anterograde transport and Golgi organization in vivo, similar to its mammalian ortholog in tissue culture cells. Friggi-Grelin F, et al. Eur J Cell Biol, 2006 Nov. PMID 16904228
  2. Drosophila ataxin-2 gene encodes two differentially expressed isoforms and its function in larval fat body is crucial for development of peripheral tissues. Vianna MC, et al. FEBS Open Bio, 2016 Nov. PMID 27833845, Free PMC Article
  3. Trafficking along the secretory pathway in Drosophila cell line and tissues: a light and electron microscopy approach. Zacharogianni M, et al. Methods Cell Biol, 2013. PMID 24295299
  4. Ferritin Is Required in Multiple Tissues during Drosophila melanogaster Development. González-Morales N, et al. PLoS One, 2015. PMID 26192321, Free PMC Article
  5. A Conserved Di-Basic Motif of Drosophila Crumbs Contributes to Efficient ER Export. Kumichel A, et al. Traffic, 2015 Jun. PMID 25753515, Free PMC Article

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Essential Role of COPII Proteins in Maintaining the Contractile Ring Anchoring to the Plasma Membrane during Cytokinesis in Drosophila Male Meiosis.
    Title: Essential Role of COPII Proteins in Maintaining the Contractile Ring Anchoring to the Plasma Membrane during Cytokinesis in Drosophila Male Meiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle budding IEA
Inferred from Electronic Annotation
more info
  
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_positive_effect chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin-based larval cuticle pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix constituent secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in larval chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect lumen formation, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of COPII vesicle coating ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat IEA
Inferred from Electronic Annotation
more info
  
part_of COPII vesicle coat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of COPII vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in COPII-coated ER to Golgi transport vesicle TAS
Traceable Author Statement
more info
 PubMed 
located_in Golgi stack IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
secretory 23
Names
CG1250-PA
CG1250-PB
CG1250-PD
CG1250-PE
CG1250-PF
CG1250-PG
CG1250-PH
Sec23 ortholog
Sec23-PA
Sec23-PB
Sec23-PD
Sec23-PE
Sec23-PF
Sec23-PG
Sec23-PH
coat protein II
dendritic arbor reduction 2
haunted
sec23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5649065..5652629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260005.2 → NP_001246934.1  secretory 23, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246934.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6T4, Q8IGT0
    Conserved Domains (6) summary
    cd11287
    Location:618 → 738
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12 → 778
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126 → 396
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:58 → 97
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:530 → 623
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:409 → 512
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

  2. NM_169089.4 → NP_730979.1  secretory 23, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730979.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGT0, Q9VNF8
    Related
    FBpp0078359
    Conserved Domains (6) summary
    cd11287
    Location:618 → 738
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12 → 771
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126 → 396
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:58 → 97
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:530 → 623
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:409 → 512
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

  3. NM_169088.2 → NP_730978.1  secretory 23, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730978.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGT0, Q9VNF8
    Related
    FBpp0078360
    Conserved Domains (6) summary
    cd11287
    Location:618 → 738
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12 → 771
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126 → 396
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:58 → 97
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:530 → 623
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:409 → 512
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

  4. NM_001260003.1 → NP_001246932.1  secretory 23, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246932.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K5Z8, Q8IGT0
    Conserved Domains (6) summary
    cd11287
    Location:618 → 738
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12 → 779
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126 → 396
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:58 → 97
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:530 → 623
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:409 → 512
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

  5. NM_001260004.1 → NP_001246933.1  secretory 23, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246933.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6T4, Q8IGT0
    Conserved Domains (6) summary
    cd11287
    Location:618 → 738
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12 → 778
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126 → 396
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:58 → 97
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:530 → 623
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:409 → 512
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

  6. NM_001300255.1 → NP_001287184.1  secretory 23, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287184.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGT0, Q9VNF8
    Conserved Domains (6) summary
    cd11287
    Location:618 → 738
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12 → 771
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126 → 396
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:58 → 97
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:530 → 623
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:409 → 512
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

  7. NM_001275365.1 → NP_001262294.1  secretory 23, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262294.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGT0, Q9VNF8
    Conserved Domains (6) summary
    cd11287
    Location:618 → 738
    Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
    PLN00162
    Location:12 → 771
    PLN00162; transport protein sec23; Provisional
    cd01478
    Location:126 → 396
    Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam04810
    Location:58 → 97
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:530 → 623
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:409 → 512
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K5Z8 A0A0B4K5Z8
A0A0B4K6T4 A0A0B4K6T4
Q8IGT0 Q8IGT0
Q95TD2 Q95TD2
Q9NFN9 Q9NFN9
Q9VNF8 Q9VNF8

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