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Sec23 - Secretory 23

Predicted to enable GTPase activator activity. Involved in several processes, including chitin-based larval cuticle pattern formation; protein localization to cell surface; and secretion by cell. Acts upstream of with a positive effect on chitin-based cuticle development and lumen formation, open tracheal system. Located in Golgi stack and endoplasmic reticulum exit site. Part of COPII vesicle coat. Is expressed in several structures, including adult head; embryonic proventriculus inner layer; foregut primordium; gland; and gut section. Human ortholog(s) of this gene implicated in Cowden syndrome 7; congenital dyserythropoietic anemia type II; and craniolenticulosutural dysplasia. Orthologous to several human genes including SEC23B (SEC23 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa