U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MIR153-1 microRNA 153-1 [ Homo sapiens (human) ]

Gene ID: 406944, updated on 2-Nov-2024

Summary

Official Symbol
MIR153-1provided by HGNC
Official Full Name
microRNA 153-1provided by HGNC
Primary source
HGNC:HGNC:31539
See related
Ensembl:ENSG00000207647 miRBase:MI0000463; AllianceGenome:HGNC:31539
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIRN153-1; mir-153-1
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MIR153-1 in Genome Data Viewer
Location:
2q35
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (219294111..219294200, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219778863..219778952, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220158833..220158922, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17148 Neighboring gene tubulin alpha 4a Neighboring gene tubulin alpha 4b Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220142208-220142912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:220150891-220151858 Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene Sharpr-MPRA regulatory region 13803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17149 Neighboring gene protein tyrosine phosphatase receptor type N Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:220199445-220200644 Neighboring gene regulated endocrine specific protein 18 Neighboring gene uncharacterized LOC107985835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17150

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_029688.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC114803
    Related
    ENST00000384914.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    219294111..219294200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219778863..219778952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)