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CG1239 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40706, updated on 9-Dec-2024

Summary

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Official Symbol
CG1239provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037368
Locus tag
Dmel_CG1239
See related
AllianceGenome:FB:FBgn0037368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BCDIN3D; cg1239; Dmel\CG1239
Summary
Enables U6 snRNA binding activity. Involved in snRNA methylation. Located in nucleus. Is expressed in organism. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG1239 in Genome Data Viewer
Location:
83C1-83C1; 3-47.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5733513..5734702)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1559235..1560424)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene castor Neighboring gene long non-coding RNA:CR44924 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Symplekin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for capping and the stabilization of U6 and 7SK snRNAs. Peng Q, et al. Sci Adv, 2023 Dec 15. PMID 38100593, Free PMC Article
  2. RNA methyltransferase BCDIN3D is crucial for female fertility and miRNA and mRNA profiles in Drosophila ovaries. Zhu L, et al. PLoS One, 2019. PMID 31145769, Free PMC Article
  3. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Tatomer DC, et al. Nucleus, 2014. PMID 25493544, Free PMC Article
  4. Genome-wide analysis of nuclear mRNA export pathways in Drosophila. Herold A, et al. EMBO J, 2003 May 15. PMID 12743041, Free PMC Article
  5. Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Rehwinkel J, et al. Nat Struct Mol Biol, 2004 Jun. PMID 15133499

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U6 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in snRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG1239-PA
CG1239-PB
CG1239-PC
NP_001287185.1
NP_001287186.1
NP_649577.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5733513..5734702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300256.1 → NP_001287185.1  uncharacterized protein Dmel_CG1239, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287185.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0ANN6, A0ANP4, C0MJ20, C0MJ21, Q9VNH1
    UniProtKB/TrEMBL
    A0A0B4LGT7
    Conserved Domains (2) summary
    pfam06859
    Location:191 → 299
    Bin3; Bicoid-interacting protein 3 (Bin3)
    pfam12847
    Location:109 → 233
    Methyltransf_18; Methyltransferase domain

  2. NM_001300257.1 → NP_001287186.1  uncharacterized protein Dmel_CG1239, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287186.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0ANN6, A0ANP4, C0MJ20, C0MJ21, Q9VNH1
    UniProtKB/TrEMBL
    A0A0B4LGT7
    Conserved Domains (2) summary
    pfam06859
    Location:191 → 299
    Bin3; Bicoid-interacting protein 3 (Bin3)
    pfam12847
    Location:109 → 233
    Methyltransf_18; Methyltransferase domain

  3. NM_141320.3 → NP_649577.1  uncharacterized protein Dmel_CG1239, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649577.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0ANN6, A0ANP4, C0MJ20, C0MJ21, Q9VNH1
    UniProtKB/TrEMBL
    A0A0B4LGT7
    Related
    FBpp0078369
    Conserved Domains (2) summary
    pfam06859
    Location:191 → 299
    Bin3; Bicoid-interacting protein 3 (Bin3)
    pfam12847
    Location:109 → 233
    Methyltransf_18; Methyltransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGT7 A0A0B4LGT7
Q9VNH1.2 Q9VNH1

Gene LinkOut

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