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kat-60L1 katanin p60-like 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40715, updated on 9-Dec-2024

Summary

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Official Symbol
kat-60L1provided by FlyBase
Official Full Name
katanin p60-like 1provided by FlyBase
Primary source
FLYBASE:FBgn0037375
Locus tag
Dmel_CG1193
See related
AllianceGenome:FB:FBgn0037375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1193; DmCG1193; Dmel\CG1193; Kat-60L1; kat60L1
Summary
Enables microtubule severing ATPase activity. Involved in microtubule severing; neuron remodeling; and positive regulation of dendrite morphogenesis. Located in ciliary basal body and microtubule. Is expressed in several structures, including embryonic antennal sense organ; embryonic central brain neurons; embryonic head sensory system; ganglia; and sensory cluster. Orthologous to human KATNAL1 (katanin catalytic subunit A1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See kat-60L1 in Genome Data Viewer
Location:
83C3-83C4; 3-47.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5781762..5787465)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1607484..1613187)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Secretory 8 Neighboring gene uncharacterized protein Neighboring gene jagunal Neighboring gene Histone acetyltransferase 1 Neighboring gene Regulatory particle non-ATPase 5 Neighboring gene Histone PARylation factor 1 Neighboring gene Proteasome assembly chaperone 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP). Baxter SL, et al. Dis Model Mech, 2014 Aug. PMID 24906373, Free PMC Article
  2. Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. Stewart A, et al. J Neurosci, 2012 Aug 22. PMID 22915107, Free PMC Article
  3. Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning. Tao J, et al. J Neurosci, 2011 Apr 6. PMID 21471375, Free PMC Article
  4. Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Lee HH, et al. Proc Natl Acad Sci U S A, 2009 Apr 14. PMID 19329489, Free PMC Article
  5. Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes. Zhang D, et al. J Cell Biol, 2007 Apr 23. PMID 17452528, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Katanin p60-like 1 sculpts the cytoskeleton in mechanosensory cilia.
    Title: Katanin p60-like 1 sculpts the cytoskeleton in mechanosensory cilia.
  2. The results of this study propose Kat-60L1 plays a unique role in regulating microtubules to promote terminal arborization and function of class IV sensory neuron dendrites
    Title: Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila.
  3. found a role for Katanin p60-like 1 (Kat-60L1) in facilitating dendrite severing by breaking microtubule in proximal dendrites, where the dendrites subsequently separate from the soma.
    Title: Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule severing ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule severing ATPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule severing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in microtubule severing IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
katanin p60-like 1
Names
CG1193-PA
CG1193-PB
CG1193-PC
CG1193-PD
CG1193-PE
CG1193-PF
CG1193-PG
CG1193-PH
Katanin-p60L1
kat-60L1-PA
kat-60L1-PB
kat-60L1-PC
kat-60L1-PD
kat-60L1-PE
kat-60L1-PF
kat-60L1-PG
kat-60L1-PH
katanin
NP_001163521.1
NP_001163522.1
NP_001163523.1
NP_001163524.1
NP_001163525.1
NP_001163526.1
NP_649586.1
NP_731004.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5781762..5787465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170055.1 → NP_001163526.1  katanin p60-like 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163526.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJ62
    Conserved Domains (3) summary
    smart00382
    Location:362 → 501
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:366 → 499
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:574 → 607
    Vps4_C; Vps4 C terminal oligomerization domain

  2. NM_141329.3 → NP_649586.1  katanin p60-like 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649586.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961H1
    Related
    FBpp0078276
    Conserved Domains (3) summary
    smart00382
    Location:358 → 497
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:362 → 495
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:570 → 603
    Vps4_C; Vps4 C terminal oligomerization domain

  3. NM_001170051.1 → NP_001163522.1  katanin p60-like 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163522.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJ62
    Conserved Domains (3) summary
    smart00382
    Location:362 → 501
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:366 → 499
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:574 → 607
    Vps4_C; Vps4 C terminal oligomerization domain

  4. NM_001170053.1 → NP_001163524.1  katanin p60-like 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163524.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961H1
    Conserved Domains (3) summary
    smart00382
    Location:358 → 497
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:362 → 495
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:570 → 603
    Vps4_C; Vps4 C terminal oligomerization domain

  5. NM_001170054.1 → NP_001163525.1  katanin p60-like 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163525.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4QPP5
    Conserved Domains (3) summary
    smart00382
    Location:426 → 565
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:430 → 563
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:638 → 671
    Vps4_C; Vps4 C terminal oligomerization domain

  6. NM_169105.2 → NP_731004.1  katanin p60-like 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731004.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNI0, Q9VNI1
    Related
    FBpp0078277
    Conserved Domains (3) summary
    smart00382
    Location:422 → 561
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:426 → 559
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:634 → 667
    Vps4_C; Vps4 C terminal oligomerization domain

  7. NM_001170052.1 → NP_001163523.1  katanin p60-like 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163523.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4QPP5
    Conserved Domains (3) summary
    smart00382
    Location:426 → 565
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:430 → 563
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:638 → 671
    Vps4_C; Vps4 C terminal oligomerization domain

  8. NM_001170050.1 → NP_001163521.1  katanin p60-like 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163521.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNI0, Q9VNI1
    Conserved Domains (3) summary
    smart00382
    Location:422 → 561
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:426 → 559
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam09336
    Location:634 → 667
    Vps4_C; Vps4 C terminal oligomerization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JJ62 E1JJ62
Q4QPP5 Q4QPP5
Q961H1 Q961H1
Q9VNI0 Q9VNI0

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