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Rpn5 Regulatory particle non-ATPase 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40717, updated on 9-Dec-2024

Summary

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Official Symbol
Rpn5provided by FlyBase
Official Full Name
Regulatory particle non-ATPase 5provided by FlyBase
Primary source
FLYBASE:FBgn0028690
Locus tag
Dmel_CG1100
See related
AllianceGenome:FB:FBgn0028690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1100; Dmel\CG1100; p55; rpn5; RPN5
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in adult head; adult heart; and organism. Orthologous to human PSMD12 (proteasome 26S subunit, non-ATPase 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Rpn5 in Genome Data Viewer
Location:
83C4-83C4; 3-47.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5789493..5791569)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1615215..1617291)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene jagunal Neighboring gene katanin p60-like 1 Neighboring gene Histone acetyltransferase 1 Neighboring gene Histone PARylation factor 1 Neighboring gene Proteasome assembly chaperone 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process. Tonoki A, et al. Mol Cell Biol, 2009 Feb. PMID 19075009, Free PMC Article
  2. The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Pathare GR, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22187461, Free PMC Article
  3. Assembly of the Drosophila 26 S proteasome is accompanied by extensive subunit rearrangements. Kurucz E, et al. Biochem J, 2002 Jul 15. PMID 11945175, Free PMC Article
  4. Zn2+-induced reversible dissociation of subunit Rpn10/p54 of the Drosophila 26 S proteasome. Kiss P, et al. Biochem J, 2005 Oct 15. PMID 15946124, Free PMC Article
  5. The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme. Hölzl H, et al. J Cell Biol, 2000 Jul 10. PMID 10893261, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, lid subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
regulatory particle non-ATPase 5
Names
CG1100-PA
Rpn5-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5789493..5791569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141331.3 → NP_649588.1  regulatory particle non-ATPase 5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649588.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3Z4
    Related
    FBpp0078278
    Conserved Domains (1) summary
    COG5071
    Location:13 → 496
    RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3Z4 Q9V3Z4

Gene LinkOut

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