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LOC407218 calcitonin-related polypeptide beta [ Bos taurus (domestic cattle) ]

Gene ID: 407218, updated on 1-Jan-2025

Summary

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Gene symbol
LOC407218
Gene description
calcitonin-related polypeptide beta
See related
BGD:BT22156; Ensembl:ENSBTAG00000001516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CALCB; CRSP1
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Genomic context

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See LOC407218 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (37806135..37809438, complement)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene calcitonin related polypeptide beta Neighboring gene transfer RNA tyrosine (anticodon GUA) Neighboring gene calcitonin-related polypeptide alpha Neighboring gene vacuolar protein sorting-associated protein 33A-like Neighboring gene cytochrome P450 family 2 subfamily R member 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Identification, structural determination, and biological activity of bovine and canine calcitonin receptor-stimulating peptides. Katafuchi T, et al. Biochem Biophys Res Commun, 2004 Jan 2. PMID 14672700
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC142514

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcitonin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calcitonin receptor-stimulating peptide 1
Names
CRSP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001149.2 → NP_001001149.1  calcitonin receptor-stimulating peptide 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001001149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform b which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB125101, DV827218
    UniProtKB/Swiss-Prot
    Q17Q98, Q75V95
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

  2. NM_001134662.1 → NP_001128134.1  calcitonin receptor-stimulating peptide 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001128134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC118475
    UniProtKB/Swiss-Prot
    Q75V95
    Related
    ENSBTAP00000001987.4, ENSBTAT00000001987.5
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 74
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    37806135..37809438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q75V95.1 GenPept UniProtKB/Swiss-Prot:Q75V95

Gene LinkOut

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Molecular Biology Databases
Research Materials