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Hpr1 Hpr1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40723, updated on 4-Jan-2025

Summary

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Official Symbol
Hpr1provided by FlyBase
Official Full Name
Hpr1provided by FlyBase
Primary source
FLYBASE:FBgn0037382
Locus tag
Dmel_CG2031
See related
AllianceGenome:FB:FBgn0037382
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2031; Dmel\CG2031; HPR1; Thoc1; THOC1
Summary
Involved in mRNA export from nucleus in response to heat stress. Located in nucleus. Part of THO complex. Is expressed in organism. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 86. Orthologous to human THOC1 (THO complex subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Hpr1 in Genome Data Viewer
Location:
83C4-83C4; 3-47.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5818794..5821440, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1644516..1647162, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Secretory 20 Neighboring gene degringolade

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Zhang G, et al. Cell Rep, 2018 Sep 25. PMID 30257203, Free PMC Article
  2. ENY2 protein forms a part of the THO complex of Drosophila melanogaster. Gurskiy DY, et al. Dokl Biochem Biophys, 2010 Jul-Aug. PMID 20714859
  3. A systems view of mRNP biology. Hieronymus H, et al. Genes Dev, 2004 Dec 1. PMID 15574591
  4. Transcriptional factor ENY2 promotes recruitment of the THO complex to the hsp70 gene of Drosophila melanogaster. Orlova AV, et al. Dokl Biochem Biophys, 2010 Sep-Oct. PMID 20960243
  5. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Le Thomas A, et al. Genes Dev, 2013 Feb 15. PMID 23392610, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus in response to heat stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of THO complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription export complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Hpr1
Names
CG2031-PA
Hpr1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5818794..5821440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141337.2 → NP_649594.1  Hpr1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649594.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNI8
    Related
    FBpp0078316
    Conserved Domains (2) summary
    pfam00531
    Location:606 → 687
    Death; Death domain
    pfam11957
    Location:79 → 538
    efThoc1; THO complex subunit 1 transcription elongation factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VNI8 Q9VNI8

Gene LinkOut

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