U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ano1a anoctamin 1, calcium activated chloride channel a [ Danio rerio (zebrafish) ]

Gene ID: 407698, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
ano1aprovided by ZNC
Official Full Name
anoctamin 1, calcium activated chloride channel aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-121127-3
See related
Ensembl:ENSDARG00000102335 AllianceGenome:ZFIN:ZDB-GENE-121127-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ano1
Summary
Predicted to enable protein dimerization activity. Predicted to be located in membrane. Is expressed in fast muscle cell and slow muscle cell. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ano1a in Genome Data Viewer
Location:
chromosome: 7
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (54322648..54449665, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (54052996..54170389, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene protein kinase C and casein kinase substrate in neurons 3 Neighboring gene Fas (tnfrsf6)-associated via death domain Neighboring gene zgc:153993 Neighboring gene fibroblast growth factor 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression of neuropeptides and anoctamin 1 in the embryonic and adult zebrafish intestine, revealing neuronal subpopulations and ICC-like cells. Uyttebroek L, et al. Cell Tissue Res, 2013 Nov. PMID 23881406
  2. Ca(2+)-activated Cl(-) channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration. Dayal A, et al. Nat Commun, 2019 Jan 10. PMID 30631052, Free PMC Article
  3. Characterization of lncRNAs involved in cold acclimation of zebrafish ZF4 cells. Jiang P, et al. PLoS One, 2018. PMID 29634734, Free PMC Article
  4. Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Li Z, et al. Environ Pollut, 2020 Jul. PMID 32146360
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that Cl(-) influx through calcium activated chloride channel anoctamin-1 (ANO1) plays an essential role in restricting the width of skeletal-muscle action potentials (APs) by accelerating the repolarisation phase.
    Title: Ca(2+)-activated Cl(-) channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration.
  2. The present results also indicate that the Ano1 antiserum is a selective marker of interstitial cells of Cajal - like cells in the zebrafish intestine revealing a 3-dimensional network.
    Title: Expression of neuropeptides and anoctamin 1 in the embryonic and adult zebrafish intestine, revealing neuronal subpopulations and ICC-like cells.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
anoctamin-1a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161590.1 → NP_001155062.1  anoctamin-1a

    Status: PROVISIONAL

    Source sequence(s)
    CR318608, CU928764
    UniProtKB/TrEMBL
    A0A8M1NT27, A0A8M3BBA3
    Conserved Domains (2) summary
    pfam04547
    Location:315 → 889
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:53 → 312
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    54322648..54449665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222213.1 → XP_068078314.1  anoctamin-1a isoform X2

    UniProtKB/TrEMBL
    A0A8M3BBA3

  2. XM_068222212.1 → XP_068078313.1  anoctamin-1a isoform X1

    UniProtKB/TrEMBL
    A0A8M3BBA3

  3. XM_017356841.3 → XP_017212330.1  anoctamin-1a isoform X5

    UniProtKB/TrEMBL
    A0A8M3BBA3, A0A8M6Z1H3
    Related
    ENSDARP00000138095.1, ENSDART00000167905.2

  4. XM_009303473.4 → XP_009301748.1  anoctamin-1a isoform X4

    UniProtKB/TrEMBL
    A0A8M3AUJ5, A0A8M3BBA3
    Conserved Domains (2) summary
    pfam04547
    Location:315 → 892
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:53 → 312
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

  5. XM_009303471.4 → XP_009301746.1  anoctamin-1a isoform X3

    UniProtKB/TrEMBL
    A0A8M3AUL7, A0A8M3BBA3
    Conserved Domains (2) summary
    pfam04547
    Location:353 → 930
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:91 → 350
    Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials