U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rnf5 ring finger protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 407784, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Rnf5provided by RGD
Official Full Name
ring finger protein 5provided by RGD
Primary source
RGD:1588458
See related
EnsemblRapid:ENSRNOG00000000438 AllianceGenome:RGD:1588458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Predicted to be involved in protein polyubiquitination and proteolysis involved in protein catabolic process. Predicted to act upstream of or within several processes, including negative regulation of autophagy; protein destabilization; and regulation of autophagosome assembly. Predicted to be located in endoplasmic reticulum and membrane. Orthologous to human RNF5 (ring finger protein 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 216.4), Adrenal (RPKM 112.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rnf5 in Genome Data Viewer
Location:
20p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4150032..4152593)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4145539..4147985)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4366244..4368690, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene advanced glycosylation end product-specific receptor Neighboring gene PBX homeobox 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Zhong B, et al. Immunity, 2009 Mar 20. PMID 19285439
  2. Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP). Tcherpakov M, et al. J Biol Chem, 2009 May 1. PMID 19269966, Free PMC Article
  3. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). El Khouri E, et al. J Biol Chem, 2013 Oct 25. PMID 24019521, Free PMC Article
  4. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. Kuang E, et al. PLoS Genet, 2012. PMID 23093945, Free PMC Article
  5. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC109637

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like protein conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like protein conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase RNF5
Names
RING-type E3 ubiquitin transferase RNF5
ing finger protein 5 pseudogene
ring finger protein 5, E3 ubiquitin protein ligase
NP_001102495.1
XP_063135456.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109025.2 → NP_001102495.1  E3 ubiquitin-protein ligase RNF5

    See identical proteins and their annotated locations for NP_001102495.1

    Status: VALIDATED

    Source sequence(s)
    BC088341, DY573537
    UniProtKB/Swiss-Prot
    Q5M807
    UniProtKB/TrEMBL
    A6KTG9
    Related
    ENSRNOP00000070056.3, ENSRNOT00000088244.3
    Conserved Domains (2) summary
    PLN03208
    Location:25 → 117
    PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
    cd16743
    Location:25 → 70
    RING-HC_RNF5; RING finger, HC subclass, found in RING finger protein 5 (RNF5) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    4150032..4152593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279386.1 → XP_063135456.1  E3 ubiquitin-protein ligase RNF5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWX8, A0A8L2UHC5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_004074.2: Suppressed sequence

    Description
    NG_004074.2: This RefSeq was permanently suppressed because there is evidence from cDNAs that the locus is transcribed and encodes a protein similar to that identified in other species. NG_004074.2 erroneously represented the str

  2. NG_004074.2: Suppressed sequence

    Description
    NG_004074.2: This RefSeq was permanently suppressed because there is evidence from cDNAs that the locus is transcribed and encodes a protein similar to that identified in other species. NG_004074.2 erroneously represented the str
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M807.1 GenPept UniProtKB/Swiss-Prot:Q5M807

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous