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KRIT1 KRIT1 ankyrin repeat containing [ Bos taurus (domestic cattle) ]

Gene ID: 407996, updated on 27-Dec-2024

Summary

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Official Symbol
KRIT1provided by VGNC
Official Full Name
KRIT1 ankyrin repeat containingprovided by VGNC
Primary source
VGNC:VGNC:30714
See related
BGD:BT22184; Ensembl:ENSBTAG00000002750
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
CCM1
Orthologs
human mouse all
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Genomic context

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See KRIT1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (9528491..9567845, complement)

Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 51 subfamily A member 1 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene leucine rich repeats and death domain containing 1 Neighboring gene uncharacterized LOC112446355 Neighboring gene ankyrin repeat and IBR domain containing 1 Neighboring gene small ribosomal subunit protein uS8-like Neighboring gene microRNA mir-584-5 Neighboring gene transmembrane BAX inhibitor motif containing 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. Glading A, et al. J Cell Biol, 2007 Oct 22. PMID 17954608, Free PMC Article
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
krev interaction trapped protein 1
Names
cerebral cavernous malformations 1 protein homolog
krev interaction trapped 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001166.1 → NP_001001166.1  krev interaction trapped protein 1

    See identical proteins and their annotated locations for NP_001001166.1

    Status: PROVISIONAL

    Source sequence(s)
    AY391713
    UniProtKB/Swiss-Prot
    Q6TNJ1
    UniProtKB/TrEMBL
    A0AAA9T8A8
    Conserved Domains (7) summary
    smart00295
    Location:421 → 640
    B41; Band 4.1 homologues
    cd00204
    Location:291 → 411
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:636 → 735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    pfam00373
    Location:521 → 640
    FERM_M; FERM central domain
    pfam12796
    Location:292 → 386
    Ank_2; Ankyrin repeats (3 copies)
    pfam16705
    Location:30 → 198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    sd00045
    Location:291 → 318
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    9528491..9567845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010803972.4 → XP_010802274.1  krev interaction trapped protein 1 isoform X2

    See identical proteins and their annotated locations for XP_010802274.1

    UniProtKB/TrEMBL
    A0AAA9T8A8
    Conserved Domains (5) summary
    smart00295
    Location:328 → 547
    B41; Band 4.1 homologues
    cd00204
    Location:198 → 318
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13197
    Location:543 → 642
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:198 → 225
    ANK; ANK repeat [structural motif]
    pfam16705
    Location:1 → 105
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

  2. XM_015467969.3 → XP_015323455.1  krev interaction trapped protein 1 isoform X1

    UniProtKB/TrEMBL
    A0AAA9T8A8, A7Z069
    Conserved Domains (5) summary
    smart00295
    Location:421 → 640
    B41; Band 4.1 homologues
    cd13197
    Location:636 → 735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291 → 318
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:292 → 386
    Ank_2; Ankyrin repeats (3 copies)
    pfam16705
    Location:30 → 198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

  3. XM_005205118.5 → XP_005205175.1  krev interaction trapped protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005205175.1

    UniProtKB/TrEMBL
    A0AAA9T8A8, A7Z069
    Conserved Domains (5) summary
    smart00295
    Location:421 → 640
    B41; Band 4.1 homologues
    cd13197
    Location:636 → 735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291 → 318
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:292 → 386
    Ank_2; Ankyrin repeats (3 copies)
    pfam16705
    Location:30 → 198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

  4. XM_005205119.5 → XP_005205176.1  krev interaction trapped protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005205176.1

    UniProtKB/TrEMBL
    A0AAA9T8A8, A7Z069
    Related
    ENSBTAP00000003566.4, ENSBTAT00000003566.6
    Conserved Domains (5) summary
    smart00295
    Location:421 → 640
    B41; Band 4.1 homologues
    cd13197
    Location:636 → 735
    FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
    sd00045
    Location:291 → 318
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:292 → 386
    Ank_2; Ankyrin repeats (3 copies)
    pfam16705
    Location:30 → 198
    NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

  5. XM_059885429.1 → XP_059741412.1  krev interaction trapped protein 1 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6TNJ1.1 GenPept UniProtKB/Swiss-Prot:Q6TNJ1

Gene LinkOut

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